Controversial issues in the management of older adults with early breast cancer

Anna Rachelle Mislang, Kwok Leung Cheung, Marije E. Hamaker, Ian Kunkler, Christos Markopoulos, Roberto Orecchia, Etienne Brain, Laura Biganzoli

Research output: Contribution to journalReview article

Abstract

It is well recognized that the incidence of breast cancer increases significantly with age. Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumours, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalJournal of Geriatric Oncology
Volume8
Issue number6
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • Chemotherapy
  • Early breast cancer
  • Geriatric assessment
  • Older adults
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Geriatrics and Gerontology

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  • Cite this

    Mislang, A. R., Cheung, K. L., Hamaker, M. E., Kunkler, I., Markopoulos, C., Orecchia, R., Brain, E., & Biganzoli, L. (2017). Controversial issues in the management of older adults with early breast cancer. Journal of Geriatric Oncology, 8(6), 397-402. https://doi.org/10.1016/j.jgo.2017.05.004