Controversial role of kisspeptins/KiSS-1R signaling system in tumor development

Federica Fratangelo, Maria Vincenza Carriero, Maria Letizia Motti

Research output: Contribution to journalShort surveypeer-review


KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.

Original languageEnglish
Article number192
JournalFrontiers in Endocrinology
Issue numberAPR
Publication statusPublished - Apr 30 2018


  • KiSS-1R
  • kisspeptin
  • Metastasis
  • Tumor development
  • Tumor invasion

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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