Abstract
KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.
| Original language | English |
|---|---|
| Article number | 192 |
| Journal | Frontiers in Endocrinology |
| Volume | 9 |
| Issue number | APR |
| DOIs | |
| Publication status | Published - Apr 30 2018 |
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Keywords
- KiSS-1R
- kisspeptin
- Metastasis
- Tumor development
- Tumor invasion
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Controversial role of kisspeptins/KiSS-1R signaling system in tumor development. / Fratangelo, Federica; Carriero, Maria Vincenza; Motti, Maria Letizia.
In: Frontiers in Endocrinology, Vol. 9, No. APR, 192, 30.04.2018.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - Controversial role of kisspeptins/KiSS-1R signaling system in tumor development
AU - Fratangelo, Federica
AU - Carriero, Maria Vincenza
AU - Motti, Maria Letizia
PY - 2018/4/30
Y1 - 2018/4/30
N2 - KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.
AB - KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.
KW - KiSS-1R
KW - kisspeptin
KW - Metastasis
KW - Tumor development
KW - Tumor invasion
UR - http://www.scopus.com/inward/record.url?scp=85046626066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046626066&partnerID=8YFLogxK
U2 - 10.3389/fendo.2018.00192
DO - 10.3389/fendo.2018.00192
M3 - Short survey
AN - SCOPUS:85046626066
VL - 9
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - APR
M1 - 192
ER -