Controversies in the management of gastrointestinal lymphoma

C. Tondini, M. Balzarotti, A. Santoro, G. Bonadonna

Research output: Contribution to journalArticlepeer-review


Primary gastrointestinal lymphoma represents the most frequent extranodal site of involvement of localised non-Hodgkin's lymphoma. Moreover, its incidence has been recently reported to be on the increase. However, in spite of the many studies published in the medical literature, several aspects of the management of this disease site still remain controversial. The issues include the following: appropriate histopathologic classification with a better characterisation of mucosa associated lymphoid tissue lymphoma, its relationship with centrofollicular lymphoma and the identification of peculiar behaviour; the definition of optimal staging with or without invasive procedures; the identification of consistent prognostic factors; and the exact role of surgery, radiation and chemotherapy in the treatment of early and intermediate stages of the disease. As all these issues can hardly be clarified by retrospective analysis of the published literature, gastrointestinal lymphoma is a field where clinical research is urgently warranted to answer these questions. Until then, the clinical approach must rely on wise interpretation of published experience and adopt careful decision making for individual patients.

Original languageEnglish
Pages (from-to)471-481
Number of pages11
JournalFORUM - Trends in Experimental and Clinical Medicine
Issue number5
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Medicine(all)


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