Primary gastrointestinal lymphoma represents the most frequent extranodal site of involvement of localised non-Hodgkin's lymphoma. Moreover, its incidence has been recently reported to be on the increase. However, in spite of the many studies published in the medical literature, several aspects of the management of this disease site still remain controversial. The issues include the following: appropriate histopathologic classification with a better characterisation of mucosa associated lymphoid tissue lymphoma, its relationship with centrofollicular lymphoma and the identification of peculiar behaviour; the definition of optimal staging with or without invasive procedures; the identification of consistent prognostic factors; and the exact role of surgery, radiation and chemotherapy in the treatment of early and intermediate stages of the disease. As all these issues can hardly be clarified by retrospective analysis of the published literature, gastrointestinal lymphoma is a field where clinical research is urgently warranted to answer these questions. Until then, the clinical approach must rely on wise interpretation of published experience and adopt careful decision making for individual patients.
|Number of pages||11|
|Journal||FORUM - Trends in Experimental and Clinical Medicine|
|Publication status||Published - 1993|
ASJC Scopus subject areas