Conventional and novel diagnostic biomarkers of acute myocardial infarction: A promising role for circulating microRNAs

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24 Citations (Scopus)

Abstract

Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.

Original languageEnglish
Pages (from-to)547-558
Number of pages12
JournalBiomarkers
Volume18
Issue number7
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Biomarkers
MicroRNAs
Myocardial Infarction
Necrosis
Troponin
Assays
Ischemia
Morbidity
Molecules

Keywords

  • Acute myocardial infarction
  • Biomarkers
  • Cardiac troponin
  • Diagnosis
  • MicroRNAs

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

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abstract = "Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.",
keywords = "Acute myocardial infarction, Biomarkers, Cardiac troponin, Diagnosis, MicroRNAs",
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AU - Recchioni, Rina

AU - Marcheselli, Fiorella

AU - Olivieri, Fabiola

AU - Ricci, Stefano

AU - Procopio, Antonio Domenico

AU - Antonicelli, Roberto

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AB - Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.

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KW - Biomarkers

KW - Cardiac troponin

KW - Diagnosis

KW - MicroRNAs

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