Abstract
Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.
| Original language | English |
|---|---|
| Pages (from-to) | 547-558 |
| Number of pages | 12 |
| Journal | Biomarkers |
| Volume | 18 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Acute myocardial infarction
- Biomarkers
- Cardiac troponin
- Diagnosis
- MicroRNAs
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
Cite this
Conventional and novel diagnostic biomarkers of acute myocardial infarction : A promising role for circulating microRNAs. / Recchioni, Rina; Marcheselli, Fiorella; Olivieri, Fabiola; Ricci, Stefano; Procopio, Antonio Domenico; Antonicelli, Roberto.
In: Biomarkers, Vol. 18, No. 7, 11.2013, p. 547-558.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conventional and novel diagnostic biomarkers of acute myocardial infarction
T2 - A promising role for circulating microRNAs
AU - Recchioni, Rina
AU - Marcheselli, Fiorella
AU - Olivieri, Fabiola
AU - Ricci, Stefano
AU - Procopio, Antonio Domenico
AU - Antonicelli, Roberto
PY - 2013/11
Y1 - 2013/11
N2 - Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.
AB - Biomarkers play a critical role in the diagnosis of acute myocardial infarction (AMI), especially in patients with atypical clinical and/or electrocardiographic presentation or co-morbidities, like the elderly. High-sensitivity assays based on specific biomarkers (e.g. cardiac troponins) enabling earlier AMI diagnosis have recently become available in clinical practice. Although no single biomarker of myocardial necrosis is ever likely to afford AMI diagnosis, a combination including different biomarkers for necrosis and ischemia, like new circulating molecules (microRNAs), could enhance diagnostic specificity. We review the recent literature on conventional and novel AMI biomarkers, with special emphasis on circulating microRNAs.
KW - Acute myocardial infarction
KW - Biomarkers
KW - Cardiac troponin
KW - Diagnosis
KW - MicroRNAs
UR - http://www.scopus.com/inward/record.url?scp=84888867373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888867373&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2013.833294
DO - 10.3109/1354750X.2013.833294
M3 - Article
C2 - 24025051
AN - SCOPUS:84888867373
VL - 18
SP - 547
EP - 558
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 7
ER -