Conventional split liver transplantation for two adult recipients: A recent experience in a single european center

Matteo Cescon, Gian Luca Grazi, Matteo Ravaioli, Giorgio Ercolani, Massimo Del Gaudio, Marco Vivarelli, Alessandro Cucchetti, Matteo Zanello, Gaetano Vetrone, Augusto Lauro, Antonio Daniele Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Split liver transplantation (SLT) for two adult recipients is still considered a challenging procedure, especially when subjected to model for end-stage liver disease (MELD)-based allocation criteria. Methods. Twenty-two SLTs were performed in adult recipients in a European center operating within a MELD-oriented system. Thirteen right-sided grafts and nine left-sided grafts were used. Right-sided grafts included 11 extended right grafts and two full right grafts. Left-sided grafts included six left lateral segment grafts and three full left grafts. Ninety-three percent of donors were allocated based on MELD score. Median graft-to-recipient body weight ratio was 1.53 (range 1.07-2.11) with right-sided grafts and 0.81 (range 0.67-1.11) with left-sided grafts. Liver cirrhosis (46%) and metabolic/genetic disorders (56%) were the main indications for transplant in recipients of right and left grafts, respectively. Results. Overall patient and graft survival were 90% and 86%. Patient survival was 84% in recipients of right grafts and 100% in recipients of left grafts. Graft survival was 84% and 89%, respectively. Vascular and biliary complications occurred in 14% and 4% of cases. Postoperative serum levels of total bilirubin were significantly higher in recipients of left-sided grafts versus right-sided grafts on postoperative days 7 and 14. Prothrombin activity was significantly lower in recipients of left-sided grafts versus right-sided grafts on postoperative days 3 and 7. Conclusions. SLT for two adult recipients can be successfully performed even using left lateral segments by assigning one graft according to MELD score, and with a more liberal allocation of the second graft.

Original languageEnglish
Pages (from-to)1117-1122
Number of pages6
JournalTransplantation
Volume88
Issue number9
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Adult recipients
  • Deceased donors
  • MELD score.
  • Partial grafts

ASJC Scopus subject areas

  • Transplantation

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