Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6Sey/Sey double-mutant mice

Luca Muzio, Barbara DiBenedetto, Anastassia Stoykova, Edoardo Boncinelli, Peter Gruss, Antonello Mallamaci

Research output: Contribution to journalArticle

Abstract

The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to stably activate morphogenesis of cerebral cortex and to repress that of adjacent structures, such as striatum.

Original languageEnglish
Pages (from-to)737-745
Number of pages9
JournalNature Neuroscience
Volume5
Issue number8
DOIs
Publication statusPublished - 2002

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Muzio, L., DiBenedetto, B., Stoykova, A., Boncinelli, E., Gruss, P., & Mallamaci, A. (2002). Conversion of cerebral cortex into basal ganglia in Emx2-/- Pax6Sey/Sey double-mutant mice. Nature Neuroscience, 5(8), 737-745. https://doi.org/10.1038/nn892