Conversion of in vitro cultured human monocytes into effective presenters of an HER2/neu-Encoded CTL peptide epitope

K. Wasserman, M. M. Corsi, L. Szekely, K. Kono, H. H. Maes, R. Kiessling

Research output: Contribution to journalArticle

Abstract

Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells. Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors. Herein, evidence is presented suggesting DC-like cells are superior to T2 with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalScandinavian Journal of Immunology
Volume45
Issue number6
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Immunology

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