Abstract
Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells. Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors. Herein, evidence is presented suggesting DC-like cells are superior to T2 with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma.
Original language | English |
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Pages (from-to) | 678-682 |
Number of pages | 5 |
Journal | Scandinavian Journal of Immunology |
Volume | 45 |
Issue number | 6 |
Publication status | Published - 1997 |
ASJC Scopus subject areas
- Immunology