Abstract
Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells. Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors. Herein, evidence is presented suggesting DC-like cells are superior to T2 with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 678-682 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Immunology |
| Volume | 45 |
| Issue number | 6 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Immunology
Cite this
Conversion of in vitro cultured human monocytes into effective presenters of an HER2/neu-Encoded CTL peptide epitope. / Wasserman, K.; Corsi, M. M.; Szekely, L.; Kono, K.; Maes, H. H.; Kiessling, R.
In: Scandinavian Journal of Immunology, Vol. 45, No. 6, 1997, p. 678-682.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conversion of in vitro cultured human monocytes into effective presenters of an HER2/neu-Encoded CTL peptide epitope
AU - Wasserman, K.
AU - Corsi, M. M.
AU - Szekely, L.
AU - Kono, K.
AU - Maes, H. H.
AU - Kiessling, R.
PY - 1997
Y1 - 1997
N2 - Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells. Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors. Herein, evidence is presented suggesting DC-like cells are superior to T2 with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma.
AB - Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells. Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors. Herein, evidence is presented suggesting DC-like cells are superior to T2 with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=0030923699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030923699&partnerID=8YFLogxK
M3 - Article
C2 - 9201308
AN - SCOPUS:0030923699
VL - 45
SP - 678
EP - 682
JO - Scandinavian Journal of Immunology
JF - Scandinavian Journal of Immunology
SN - 0300-9475
IS - 6
ER -