Conversion of MCI to dementia

Role of proton magnetic resonance spectroscopy

Antonio Metastasio, Patrizia Rinaldi, Roberto Tarducci, Elena Mariani, Filippo T. Feliziani, Antonio Cherubini, Gian Piero Pelliccioli, Gianni Gobbi, Umberto Senin, Patrizia Mecocci

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in brain metabolites able to detect subjects with aMCI at risk of conversion towards AD. Twenty-five subjects with aMCI and 29 normal elderly were enrolled; they underwent a comprehensive clinical and instrumental assessment, a cerebral 1H MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally. After 1 year, 5 MCI subjects became demented (progressive MCI, pMCI). Their baseline levels of metabolites were compared with those evaluated in stable MCI (sMCI) and in controls. We observed a significant difference of the NAA/Cr ratio between pMCI (1.48 ± 0.08) and sMCI (1.65 ± 0.12) and between pMCI and controls (1.63 ± 0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia.

Original languageEnglish
Pages (from-to)926-932
Number of pages7
JournalNeurobiology of Aging
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Dementia
Creatine
Alzheimer Disease
Prodromal Symptoms
Inositol
Choline
Cognitive Dysfunction
Proton Magnetic Resonance Spectroscopy
Brain
N-acetylaspartate

Keywords

  • Alzheimer's disease
  • Mild cognitive impairment
  • Proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Metastasio, A., Rinaldi, P., Tarducci, R., Mariani, E., Feliziani, F. T., Cherubini, A., ... Mecocci, P. (2006). Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy. Neurobiology of Aging, 27(7), 926-932. https://doi.org/10.1016/j.neurobiolaging.2005.05.002

Conversion of MCI to dementia : Role of proton magnetic resonance spectroscopy. / Metastasio, Antonio; Rinaldi, Patrizia; Tarducci, Roberto; Mariani, Elena; Feliziani, Filippo T.; Cherubini, Antonio; Pelliccioli, Gian Piero; Gobbi, Gianni; Senin, Umberto; Mecocci, Patrizia.

In: Neurobiology of Aging, Vol. 27, No. 7, 07.2006, p. 926-932.

Research output: Contribution to journalArticle

Metastasio, A, Rinaldi, P, Tarducci, R, Mariani, E, Feliziani, FT, Cherubini, A, Pelliccioli, GP, Gobbi, G, Senin, U & Mecocci, P 2006, 'Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy', Neurobiology of Aging, vol. 27, no. 7, pp. 926-932. https://doi.org/10.1016/j.neurobiolaging.2005.05.002
Metastasio, Antonio ; Rinaldi, Patrizia ; Tarducci, Roberto ; Mariani, Elena ; Feliziani, Filippo T. ; Cherubini, Antonio ; Pelliccioli, Gian Piero ; Gobbi, Gianni ; Senin, Umberto ; Mecocci, Patrizia. / Conversion of MCI to dementia : Role of proton magnetic resonance spectroscopy. In: Neurobiology of Aging. 2006 ; Vol. 27, No. 7. pp. 926-932.
@article{8e9db30d24df41988d004b2c7237c942,
title = "Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy",
abstract = "Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in brain metabolites able to detect subjects with aMCI at risk of conversion towards AD. Twenty-five subjects with aMCI and 29 normal elderly were enrolled; they underwent a comprehensive clinical and instrumental assessment, a cerebral 1H MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally. After 1 year, 5 MCI subjects became demented (progressive MCI, pMCI). Their baseline levels of metabolites were compared with those evaluated in stable MCI (sMCI) and in controls. We observed a significant difference of the NAA/Cr ratio between pMCI (1.48 ± 0.08) and sMCI (1.65 ± 0.12) and between pMCI and controls (1.63 ± 0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia.",
keywords = "Alzheimer's disease, Mild cognitive impairment, Proton magnetic resonance spectroscopy",
author = "Antonio Metastasio and Patrizia Rinaldi and Roberto Tarducci and Elena Mariani and Feliziani, {Filippo T.} and Antonio Cherubini and Pelliccioli, {Gian Piero} and Gianni Gobbi and Umberto Senin and Patrizia Mecocci",
year = "2006",
month = "7",
doi = "10.1016/j.neurobiolaging.2005.05.002",
language = "English",
volume = "27",
pages = "926--932",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Conversion of MCI to dementia

T2 - Role of proton magnetic resonance spectroscopy

AU - Metastasio, Antonio

AU - Rinaldi, Patrizia

AU - Tarducci, Roberto

AU - Mariani, Elena

AU - Feliziani, Filippo T.

AU - Cherubini, Antonio

AU - Pelliccioli, Gian Piero

AU - Gobbi, Gianni

AU - Senin, Umberto

AU - Mecocci, Patrizia

PY - 2006/7

Y1 - 2006/7

N2 - Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in brain metabolites able to detect subjects with aMCI at risk of conversion towards AD. Twenty-five subjects with aMCI and 29 normal elderly were enrolled; they underwent a comprehensive clinical and instrumental assessment, a cerebral 1H MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally. After 1 year, 5 MCI subjects became demented (progressive MCI, pMCI). Their baseline levels of metabolites were compared with those evaluated in stable MCI (sMCI) and in controls. We observed a significant difference of the NAA/Cr ratio between pMCI (1.48 ± 0.08) and sMCI (1.65 ± 0.12) and between pMCI and controls (1.63 ± 0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia.

AB - Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in brain metabolites able to detect subjects with aMCI at risk of conversion towards AD. Twenty-five subjects with aMCI and 29 normal elderly were enrolled; they underwent a comprehensive clinical and instrumental assessment, a cerebral 1H MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally. After 1 year, 5 MCI subjects became demented (progressive MCI, pMCI). Their baseline levels of metabolites were compared with those evaluated in stable MCI (sMCI) and in controls. We observed a significant difference of the NAA/Cr ratio between pMCI (1.48 ± 0.08) and sMCI (1.65 ± 0.12) and between pMCI and controls (1.63 ± 0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia.

KW - Alzheimer's disease

KW - Mild cognitive impairment

KW - Proton magnetic resonance spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=33646524564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646524564&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2005.05.002

DO - 10.1016/j.neurobiolaging.2005.05.002

M3 - Article

VL - 27

SP - 926

EP - 932

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 7

ER -