Cooperation between insulin and leptin in the modulation of vascular tone

Carmine Vecchione, Alessandra Aretini, Angelo Maffei, Gennaro Marino, Giulio Selvetella, Roberta Poulet, Valentina Trimarco, Giacomo Frati, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review


High levels of insulin and leptin have been reported in human hypertension, suggesting a role for these metabolic hormones in blood pressure homeostasis. These hormones interact on intermediate metabolism, but nothing is known about their interaction at the vascular level. Our data demonstrate that insulin (0.6 nmol/L) is able to enhance vasodilation induced by leptin (10-11 to 10-6 mol/L; percentage change in maximal vasodilation, 39±3% vs 26±2%; n=6, P473 and Thr308 and of endothelial NO synthase in Ser1177. In conclusion, our data demonstrate that insulin and leptin cooperate in the modulation of vascular tone through enhancement of endothelial NO release. This phenomenon could have a major impact on the regulation of the cardiovascular system, principally in those clinical conditions characterized by endothelial NO dysfunction and metabolic disorders, such as arterial hypertension.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
Issue number2
Publication statusPublished - Aug 1 2003


  • Endothelium-derived factors
  • Insulin
  • Leptin
  • Nitric oxide synthase
  • Phosphorylation
  • Vasorelaxation

ASJC Scopus subject areas

  • Internal Medicine


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