Copper-doped bioactive glass as filler for PMMA-based bone cements: Morphological, mechanical, reactivity, and preliminary antibacterial characterization

Marta Miola, Andrea Cochis, Ajay Kumar, Carla Renata Arciola, Lia Rimondini, Enrica Verné

Research output: Contribution to journalArticlepeer-review

Abstract

To promote osteointegration and simultaneously limit bacterial contamination without using antibiotics, we designed innovative composite cements containing copper (Cu)-doped bioactive glass powders. Cu-doped glass powders were produced by a melt and quenching process, followed by an ion-exchange process in a Cu salt aqueous solution. Cu-doped glass was incorporated into commercial polymethyl methacrylate (PMMA)-based cements with different viscosities. The realized composites were characterized in terms of morphology, composition, leaching ability, bioactivity, mechanical, and antibacterial properties. Glass powders appeared well distributed and exposed on the PMMA surface. Composite cements showed good bioactivity, evidencing hydroxyapatite precipitation on the sample surfaces after seven days of immersion in simulated body fluid. The leaching test demonstrated that composite cements released a significant amount of copper, with a noticeable antibacterial effect toward Staphylococcus epidermidis strain. Thus, the proposed materials represent an innovative and multifunctional tool for orthopedic prostheses fixation, temporary prostheses, and spinal surgery.

Original languageEnglish
Article number961
Pages (from-to)1-13
Number of pages13
JournalMaterials
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 6 2018

Keywords

  • Antimicrobial
  • Bioactive glass
  • Composite bone cement
  • Copper

ASJC Scopus subject areas

  • Materials Science(all)

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