Cord blood basophil releasability

Evaluation of histamine release and leukotriene c4 generation

Antonio Miadonna, Ennio Leggieri, Alberto Tedeschi, Maurizio Lorini, Giuliano Motta, Gina Lucci, Marco Froldi, Antonio Marini, Carlo Zanussi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study was performed to evaluate mediator (histamine and leukotriene C4) release from cord blood and adult blood basophils, challenged with IgE-independent (calcium ionophore A23187) and IgE-mediated (anti-IgE) stimuli. IgE-independent mediator release was similar in adult blood and umbilical blood basophils. Conversely, the anti-IgE-induced histamine and immunoreactive leukotriene C4 (iLTC4) release was significantly reduced in cord blood basophils. Passive sensitization with an IgE-rich serum was followed by a significant increase in the number of eluted IgE molecules from cord blood basophils and by an increase in IgE-mediated histamine release. Iltc4 production was not affected by passive sensitization of umbilical blood basophils. The IgE-dependent mediator release from cord blood basophils was not correlated with the number of cell-bound IgE. In addition, histamine secretion and leukotriene C4 production from cord blood basophils seem to be independent events.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume86
Issue number1
DOIs
Publication statusPublished - 1988

Fingerprint

Leukotriene C4
Basophils
Histamine Release
Fetal Blood
Immunoglobulin E
Histamine
Umbilicus
Calcium Ionophores
Calcimycin
Cell Count

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Miadonna, A., Leggieri, E., Tedeschi, A., Lorini, M., Motta, G., Lucci, G., ... Zanussi, C. (1988). Cord blood basophil releasability: Evaluation of histamine release and leukotriene c4 generation. International Archives of Allergy and Immunology, 86(1), 42-47. https://doi.org/10.1159/000234604

Cord blood basophil releasability : Evaluation of histamine release and leukotriene c4 generation. / Miadonna, Antonio; Leggieri, Ennio; Tedeschi, Alberto; Lorini, Maurizio; Motta, Giuliano; Lucci, Gina; Froldi, Marco; Marini, Antonio; Zanussi, Carlo.

In: International Archives of Allergy and Immunology, Vol. 86, No. 1, 1988, p. 42-47.

Research output: Contribution to journalArticle

Miadonna, A, Leggieri, E, Tedeschi, A, Lorini, M, Motta, G, Lucci, G, Froldi, M, Marini, A & Zanussi, C 1988, 'Cord blood basophil releasability: Evaluation of histamine release and leukotriene c4 generation', International Archives of Allergy and Immunology, vol. 86, no. 1, pp. 42-47. https://doi.org/10.1159/000234604
Miadonna, Antonio ; Leggieri, Ennio ; Tedeschi, Alberto ; Lorini, Maurizio ; Motta, Giuliano ; Lucci, Gina ; Froldi, Marco ; Marini, Antonio ; Zanussi, Carlo. / Cord blood basophil releasability : Evaluation of histamine release and leukotriene c4 generation. In: International Archives of Allergy and Immunology. 1988 ; Vol. 86, No. 1. pp. 42-47.
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