Cord blood transplantation for children with acute leukemia

F. Locatelli, V. Rocha, C. Chastang, W. Arcese, J. Ortega, R. Pasquini, G. Souillet, E. Ferreira, P. Comoli, E. Gluckman

Research output: Contribution to journalArticle

Abstract

Over the past decade, allogeneic cord blood transplantation (CBT) has been widely used for treating patients with malignant disorders. However, the reported low incidence of GVHD observed after allogeneic CBT might be a major drawback in leukemic recipients and at present it is not clear whether CBT really predisposes patients to an increased risk of leukemia relapse. In order to further elucidate the role of CBT in children with hematological malignancies, 54 patients with ALL or AML given either a related (31 cases) or an unrelated (23 cases) CBT in 25 centers participating in the Eurocord Registry were analyzed. Overall survival of related and unrelated CBT recipients was substantially similar, the most important factor influencing patients' outcome being disease state at time of transplantation. In fact, due to a markedly increased relapse rate, poor-risk children (ie patients transplanted in more advanced disease) experienced a significantly worse EFS than those given CBT in a more favorable disease phase (ie CR1 or CR2). These data confirm that allogeneic CBT from either a related or an unrelated donor is a feasible procedure able to cure a significant proportion of children with acute leukemia, especially if transplanted in a favorable phase of disease.

Original languageEnglish
JournalBone Marrow Transplantation
Volume21
Issue numberSUPPL. 3
Publication statusPublished - 1998

Keywords

  • Acute leukemia
  • Cord blood transplantation
  • Graft versus-leukemia
  • Graft-versus-host disease
  • Leukemia relapse

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Locatelli, F., Rocha, V., Chastang, C., Arcese, W., Ortega, J., Pasquini, R., Souillet, G., Ferreira, E., Comoli, P., & Gluckman, E. (1998). Cord blood transplantation for children with acute leukemia. Bone Marrow Transplantation, 21(SUPPL. 3).