Core histone acetylation during lymphocyte activation

Aldo Profumo, Flavia Querzola, Giorgio Vidali

Research output: Contribution to journalArticlepeer-review

Abstract

Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalFEBS Letters
Volume250
Issue number2
DOIs
Publication statusPublished - Jul 3 1989

Keywords

  • Histone acetylation
  • Lymphocyte

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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