Core histone acetylation during lymphocyte activation

Aldo Profumo; Flavia Querzola; Giorgio Vidali

doi:10.1016/0014-5793(89)80742-2

Core histone acetylation during lymphocyte activation

Aldo Profumo, Flavia Querzola, Giorgio Vidali

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.

Original language	English
Pages (from-to)	297-300
Number of pages	4
Journal	FEBS Letters
Volume	250
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80742-2
Publication status	Published - Jul 3 1989

Keywords

Histone acetylation
Lymphocyte

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/0014-5793(89)80742-2

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title = "Core histone acetylation during lymphocyte activation",

abstract = "Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.",

keywords = "Histone acetylation, Lymphocyte",

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AU - Querzola, Flavia

AU - Vidali, Giorgio

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N2 - Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.

AB - Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.

KW - Histone acetylation

KW - Lymphocyte

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Core histone acetylation during lymphocyte activation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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