Abstract
Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.
| Original language | English |
|---|---|
| Pages (from-to) | 297-300 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 250 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 3 1989 |
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Keywords
- Histone acetylation
- Lymphocyte
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Core histone acetylation during lymphocyte activation. / Profumo, Aldo; Querzola, Flavia; Vidali, Giorgio.
In: FEBS Letters, Vol. 250, No. 2, 03.07.1989, p. 297-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Core histone acetylation during lymphocyte activation
AU - Profumo, Aldo
AU - Querzola, Flavia
AU - Vidali, Giorgio
PY - 1989/7/3
Y1 - 1989/7/3
N2 - Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.
AB - Histone acetylation has been followed in cultures of human lymphocytes, in PHA-stimulated lymphocytes and in mixed lymphocytes obtained from identical twins and from unrelated donors. A computer assisted analysis of two-dimensional gels and autoradiograms revealed that in cultured lymphocytes only H3 and H4 core histones incorporate labeled acetate and that two H3 variants greatly differ in their rate of acetate uptake.
KW - Histone acetylation
KW - Lymphocyte
UR - http://www.scopus.com/inward/record.url?scp=0024403496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024403496&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(89)80742-2
DO - 10.1016/0014-5793(89)80742-2
M3 - Article
C2 - 2473917
AN - SCOPUS:0024403496
VL - 250
SP - 297
EP - 300
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2
ER -