Coregulators and inflammation

Serena Ghisletti, Wendy Huang, Christopher K. Glass

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inflammation is an essential host response that serves to direct the immune system to sites of infection, but when excessive, it contributes to the pathogenesis of numerous diseases that include atherosclerosis, diabetes and cancer. Responses to microbial pathogens are initially mediated by pattern-recognition receptors that regulate the expression and activities of transcription factors that include nuclear factor B (NF-B) and interferon-regulatory factors (IRFs). These transcription factors in turn bind to specific DNA response elements on inflammatory target genes and stimulate transcription by recruiting coactivators. In addition to this activation step, recent studies indicate that the transcriptional activation of many inflammatory genes also requires a signal-dependent derepression step, involving active removal of corepressor complexes. Several members of the nuclear receptor superfamily, including the glucocorticoid receptor, peroxisome proliferator-activated receptors, and the liver X receptors, can counterregulate inflammatory responses in a ligand-dependent manner by inhibiting the formation of activator/coactivator complexes or by preventing the signal-dependent clearance of corepressor complexes. These activities influence the development of innate and adaptive immune responses to microbial infections and represent significant targets for therapeutic intervention in inflammatory diseases.

Original languageEnglish
Title of host publicationNR Coregulators and Human Diseases
PublisherWorld Scientific Publishing Co.
Pages454-479
Number of pages26
ISBN (Print)9789812819178, 9812705368, 9789812705365
DOIs
Publication statusPublished - Jan 1 2008

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Co-Repressor Proteins
Transcription Factors
Interferon Regulatory Factors
Inflammation
Pattern Recognition Receptors
Peroxisome Proliferator-Activated Receptors
Glucocorticoid Receptors
Response Elements
Adaptive Immunity
Cytoplasmic and Nuclear Receptors
Infection
Innate Immunity
Transcriptional Activation
Genes
Immune System
Atherosclerosis
Ligands
DNA
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ghisletti, S., Huang, W., & Glass, C. K. (2008). Coregulators and inflammation. In NR Coregulators and Human Diseases (pp. 454-479). World Scientific Publishing Co.. https://doi.org/10.1142/9789812819178_0014

Coregulators and inflammation. / Ghisletti, Serena; Huang, Wendy; Glass, Christopher K.

NR Coregulators and Human Diseases. World Scientific Publishing Co., 2008. p. 454-479.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ghisletti, S, Huang, W & Glass, CK 2008, Coregulators and inflammation. in NR Coregulators and Human Diseases. World Scientific Publishing Co., pp. 454-479. https://doi.org/10.1142/9789812819178_0014
Ghisletti S, Huang W, Glass CK. Coregulators and inflammation. In NR Coregulators and Human Diseases. World Scientific Publishing Co. 2008. p. 454-479 https://doi.org/10.1142/9789812819178_0014
Ghisletti, Serena ; Huang, Wendy ; Glass, Christopher K. / Coregulators and inflammation. NR Coregulators and Human Diseases. World Scientific Publishing Co., 2008. pp. 454-479
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