Coriander (Coriandrum sativum) Essential Oil: Effect on Multidrug Resistant Uropathogenic Escherichia coli

Francesca Scazzocchio, Lorenzo Mondì, Maria Grazia Ammendolia, Paola Goldoni, Antonella Comanducci, Massimiliano Marazzato, Maria Pia Conte, Federica Rinaldi, Maria Elisa Crestoni, Caterina Fraschetti, Catia Longhi

Research output: Contribution to journalArticlepeer-review


Coriander (Coriandrum sativum L., Apiaceae) is known for its antimicrobial activity and the aim of this study was to investigate the effect of its essential oil (CDO) against multidrug resistant uropathogenic Escherichia coli (UPEC). CDO was able to inhibit the growth of UPEC strains and propidium iodide uptake, and electron microscopy examination suggested that bacterial structural modifications occurred. The presence of CDO reduced the MIC of gentamicin. E.coli adhesion efficiency on cell monolayers and abiotic surfaces was not affected by subMIC oil concentrations; furthermore, CDO showed cytotoxic activity towards the HEp-2 tumor cell line. These findings contribute to the knowledge about essential oils as sources of potential antimicrobial agents against uropathogenic E. coli and encourage further investigations.

Original languageEnglish
Pages (from-to)623-626
Number of pages4
JournalNatural Product Communications
Issue number4
Publication statusPublished - Jan 1 2017


  • Antibiotic resistance
  • Coriandrum sativum
  • Escherichia coli
  • Essential oil
  • Urinary tract infections
  • Uropathogenic Escherichia coli

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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