Purpose: Given that a previous study found that corneal asphericity influences the refractive outcome of intraocular lens (IOL) power calculation by means of thin-lens formulas in eyes with spherical IOLs, the authors aimed to verify whether such influence can also be observed in eyes with aspherical IOLs. Methods: In this retrospective comparative case series, IOL power was calculated with the Haigis, Hoffer Q, Holladay 1, and SRK/T formulas in two groups of eyes undergoing phacoemulsification and implantation of an aspherical IOL (Acrysof SN60WF; Alcon Laboratories, Inc., Fort Worth, TX). For each formula, the refractive prediction error was calculated once the constants had been optimized. Biometric data were obtained by partial coherence interferometry in one group and immersion ultrasound biometry and corneal topography in the other. Corneal asphericity was assessed by two different corneal topographers in the optical biometry group (Magellan; Nidek, Gamagori, Japan) and ultrasound biometry group (Keratron, Optikon 2000 Spa, Rome, Italy). Results: The mean Q-value was -0.12 ± 0.08 in the optical biometry group (n = 51) and -0.22 ± 0.14 in the ultrasound biometry group (n = 79). In both groups, linear regression disclosed a statistically significant correlation between the Q-value and the prediction error (the only exception being the SRK/T formula). More negative Q-values were correlated to a positive prediction error, indicating a myopic outcome for prolate corneas. However, the correlation coefficients were lower than those previously reported for spherical IOLs. Conclusions: Corneal asphericity also influences the refractive outcomes of IOL power calculation by thin-lens formulas when aspherical IOLs are implanted, although this influence is exerted to a lesser degree compared to spherical IOLs.
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