Corneal biomechanical characteristics in patients with diabetes mellitus

Aachal Kotecha, Francesco Oddone, Christos Sinapis, Ahmed Elsheikh, Dimitros Sinapis, Angelos Sinapis, David F. Garway-Heath

Research output: Contribution to journalArticle

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Abstract

Purpose: To compare the corneal biomechanical properties in eyes of patients with diabetes mellitus and in those of subjects without diabetes mellitus. Setting: Hospital eye clinic. Design: Comparative case series. Methods: Corneal hysteresis (CH) and corneal response factor (CRF) were measured in diabetic patients and nondiabetic subjects using the Ocular Response Analyzer. Central corneal thickness (CCT) and intraocular pressure (IOP) were also measured. Differences in corneal biomechanical properties were determined using a 1-way analysis of variance. Interassociations between ocular and diabetic parameters were also evaluated. Results: Sixty-one eyes of 61 diabetic patients and 123 eyes of 123 nondiabetic subjects were evaluated. The CRF was significantly greater in the eyes of diabetic patients (mean difference, 1.09 mm Hg; 95% confidence interval [CI], 0.49-1.69; P = .001). There were no significant differences in CCT or CH between groups (CH: mean difference, 0.38 mm Hg; 95% CI, -0.21 to 0.97 mm Hg; P = .21; CCT: mean difference, 0.13 μm; 95% CI, -10.6 to 10.8 μm; P =.98). Corneal hysteresis and CRF were weakly correlated with blood glucose concentration (slopes: CH: 0.28; 95% CI, 0.03-0.50; P = .03; CRF: 0.27; 95% CI 0.02-0.49; P = .04). In a multiple regression analysis, the effects of blood glucose concentration were reduced and age and CCT became significant predictors of CH and CRF. Conclusions: The eyes in diabetic patients displayed altered corneal biomechanics that may be related to blood glucose concentration. Further studies are required to establish the effects of long-term poor glucose control on corneal biomechanical properties and how this might affect the diabetic patient's response to refractive surgery procedures. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

Original languageEnglish
Pages (from-to)1822-1828
Number of pages7
JournalJournal of Cataract and Refractive Surgery
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2010

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Diabetes Mellitus
Confidence Intervals
Blood Glucose
Refractive Surgical Procedures
Disclosure
Intraocular Pressure
Biomechanical Phenomena
Analysis of Variance
Regression Analysis
Glucose

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery

Cite this

Kotecha, A., Oddone, F., Sinapis, C., Elsheikh, A., Sinapis, D., Sinapis, A., & Garway-Heath, D. F. (2010). Corneal biomechanical characteristics in patients with diabetes mellitus. Journal of Cataract and Refractive Surgery, 36(11), 1822-1828. https://doi.org/10.1016/j.jcrs.2010.08.027

Corneal biomechanical characteristics in patients with diabetes mellitus. / Kotecha, Aachal; Oddone, Francesco; Sinapis, Christos; Elsheikh, Ahmed; Sinapis, Dimitros; Sinapis, Angelos; Garway-Heath, David F.

In: Journal of Cataract and Refractive Surgery, Vol. 36, No. 11, 11.2010, p. 1822-1828.

Research output: Contribution to journalArticle

Kotecha, A, Oddone, F, Sinapis, C, Elsheikh, A, Sinapis, D, Sinapis, A & Garway-Heath, DF 2010, 'Corneal biomechanical characteristics in patients with diabetes mellitus', Journal of Cataract and Refractive Surgery, vol. 36, no. 11, pp. 1822-1828. https://doi.org/10.1016/j.jcrs.2010.08.027
Kotecha, Aachal ; Oddone, Francesco ; Sinapis, Christos ; Elsheikh, Ahmed ; Sinapis, Dimitros ; Sinapis, Angelos ; Garway-Heath, David F. / Corneal biomechanical characteristics in patients with diabetes mellitus. In: Journal of Cataract and Refractive Surgery. 2010 ; Vol. 36, No. 11. pp. 1822-1828.
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AU - Sinapis, Angelos

AU - Garway-Heath, David F.

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AB - Purpose: To compare the corneal biomechanical properties in eyes of patients with diabetes mellitus and in those of subjects without diabetes mellitus. Setting: Hospital eye clinic. Design: Comparative case series. Methods: Corneal hysteresis (CH) and corneal response factor (CRF) were measured in diabetic patients and nondiabetic subjects using the Ocular Response Analyzer. Central corneal thickness (CCT) and intraocular pressure (IOP) were also measured. Differences in corneal biomechanical properties were determined using a 1-way analysis of variance. Interassociations between ocular and diabetic parameters were also evaluated. Results: Sixty-one eyes of 61 diabetic patients and 123 eyes of 123 nondiabetic subjects were evaluated. The CRF was significantly greater in the eyes of diabetic patients (mean difference, 1.09 mm Hg; 95% confidence interval [CI], 0.49-1.69; P = .001). There were no significant differences in CCT or CH between groups (CH: mean difference, 0.38 mm Hg; 95% CI, -0.21 to 0.97 mm Hg; P = .21; CCT: mean difference, 0.13 μm; 95% CI, -10.6 to 10.8 μm; P =.98). Corneal hysteresis and CRF were weakly correlated with blood glucose concentration (slopes: CH: 0.28; 95% CI, 0.03-0.50; P = .03; CRF: 0.27; 95% CI 0.02-0.49; P = .04). In a multiple regression analysis, the effects of blood glucose concentration were reduced and age and CCT became significant predictors of CH and CRF. Conclusions: The eyes in diabetic patients displayed altered corneal biomechanics that may be related to blood glucose concentration. Further studies are required to establish the effects of long-term poor glucose control on corneal biomechanical properties and how this might affect the diabetic patient's response to refractive surgery procedures. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned.

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