TY - JOUR
T1 - Corneal collagen cross-linking window absorption
AU - Rosetta, Pietro
AU - Vinciguerra, Riccardo
AU - Romano, Mario R.
AU - Vinciguerra, Paolo
PY - 2013/4
Y1 - 2013/4
N2 - PURPOSE:: To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea. METHODS:: Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer. RESULTS:: In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection. CONCLUSION:: CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.
AB - PURPOSE:: To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea. METHODS:: Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer. RESULTS:: In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection. CONCLUSION:: CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.
KW - corneal infectious keratitis
KW - riboflavin
KW - ultraviolet corneal cross-linking
UR - http://www.scopus.com/inward/record.url?scp=84875211557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875211557&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e318259c9bb
DO - 10.1097/ICO.0b013e318259c9bb
M3 - Article
C2 - 22895045
AN - SCOPUS:84875211557
VL - 32
SP - 550
EP - 554
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 4
ER -