Corneal collagen cross-linking window absorption

Pietro Rosetta, Riccardo Vinciguerra, Mario R. Romano, Paolo Vinciguerra

Research output: Contribution to journalArticlepeer-review


PURPOSE:: To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea. METHODS:: Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer. RESULTS:: In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection. CONCLUSION:: CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
Issue number4
Publication statusPublished - Apr 2013


  • corneal infectious keratitis
  • riboflavin
  • ultraviolet corneal cross-linking

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Corneal collagen cross-linking window absorption'. Together they form a unique fingerprint.

Cite this