Corneal diabetic neuropathy: A confocal microscopy study

Edoardo Midena, Erica Brugin, Alessandra Ghirlando, Marco Sommavilla, Angelo Avogaro

Research output: Contribution to journalArticlepeer-review


PURPOSE: To evaluate the role of corneal confocal microscopy in the diagnosis of morphologic damage of the corneal sub-basal nerve plexus in diabetic patients and to correlate corneal confocal microscopy findings with peripheral diabetic neuropathy. METHODS: Corneal sub-basal nerve plexus parameters were quantified by corneal confocal microscopy in 42 diabetic patients and 27 age-matched controls. The parameters quantified were the number of fibers, the tortuosity of fibers, the number of headings, and the branching pattern of the fibers. Peripheral neuropathy was also quantified using the Michigan Neuropathy Screening Instrument. RESULTS: The number of fibers, number of headings, and branching pattern of fibers significantly decreases in diabetic patients versus control subjects (P

Original languageEnglish
JournalJournal of Refractive Surgery
Issue number9 SUPPL.
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Ophthalmology


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