Corneal light backscattering after transepithelial corneal crosslinking using iontophoresis in donor human corneal tissue

Marco Lombardo, Sebastiano Serrao, Giovanni Carbone, Giuseppe Lombardo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose To analyze the spatial distribution and time course of corneal light backscattering before and after transepithelial corneal crosslinking using iontophoresis. Setting Fondazione G.B. Bietti-IRCCS, Rome, Italy. Design Experimental study. Methods Three donor human eyes with an intact corneal epithelium had transepithelial iontophoresis corneal crosslinking (using rapid ultraviolet-A [UVA] irradiation), and 3 donor eyes without corneal epithelium had standard corneal crosslinking (using standard UVA irradiation). In addition, 3 donor eyes had iontophoresis and rapid corneal crosslinking after corneal deepithelialization (epi-off iontophoresis corneal crosslinking). Scheimpflug images (Pentacam HR) of each eye globe were acquired before and immediately after administration of riboflavin 0.1% solutions and 5, 10, 30, and 120 minutes after the corneal crosslinking procedures. Corneal light backscattering was quantified across the anterior 280 μm thickness at several points from the optical center to 3.0 mm from the center. Results Light backscattering significantly increased after iontophoresis (P

Original languageEnglish
Pages (from-to)635-643
Number of pages9
JournalJournal of Cataract and Refractive Surgery
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

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Iontophoresis
Light
Corneal Epithelium
Spatial Analysis
Riboflavin
Italy
Research Design

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Surgery
  • Medicine(all)

Cite this

Corneal light backscattering after transepithelial corneal crosslinking using iontophoresis in donor human corneal tissue. / Lombardo, Marco; Serrao, Sebastiano; Carbone, Giovanni; Lombardo, Giuseppe.

In: Journal of Cataract and Refractive Surgery, Vol. 41, No. 3, 01.03.2015, p. 635-643.

Research output: Contribution to journalArticle

Lombardo, Marco ; Serrao, Sebastiano ; Carbone, Giovanni ; Lombardo, Giuseppe. / Corneal light backscattering after transepithelial corneal crosslinking using iontophoresis in donor human corneal tissue. In: Journal of Cataract and Refractive Surgery. 2015 ; Vol. 41, No. 3. pp. 635-643.
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N2 - Purpose To analyze the spatial distribution and time course of corneal light backscattering before and after transepithelial corneal crosslinking using iontophoresis. Setting Fondazione G.B. Bietti-IRCCS, Rome, Italy. Design Experimental study. Methods Three donor human eyes with an intact corneal epithelium had transepithelial iontophoresis corneal crosslinking (using rapid ultraviolet-A [UVA] irradiation), and 3 donor eyes without corneal epithelium had standard corneal crosslinking (using standard UVA irradiation). In addition, 3 donor eyes had iontophoresis and rapid corneal crosslinking after corneal deepithelialization (epi-off iontophoresis corneal crosslinking). Scheimpflug images (Pentacam HR) of each eye globe were acquired before and immediately after administration of riboflavin 0.1% solutions and 5, 10, 30, and 120 minutes after the corneal crosslinking procedures. Corneal light backscattering was quantified across the anterior 280 μm thickness at several points from the optical center to 3.0 mm from the center. Results Light backscattering significantly increased after iontophoresis (P

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