Corneocyte size and cell renewal: Effects of aging and sex hormones

Enzo Berardesca, Joachim Fluhr

Research output: Chapter in Book/Report/Conference proceedingChapter


The stratum corneum is viewed currently as a layer of protein-enriched corneocytes embedded in a lipid-enriched, intercellular matrix [1], the so-called bricks and mortar model. The bricks are corneocytes surrounded by a cornified cell envelope made up of proteins, mainly loricrin, filaggrin, and involucrin, and covalently bound to the hydroxyceramide molecules of a lipid envelope. These bricks are embedded in a mortar of lipid bilayers [2-4]. The so-called mortar contains a variety of intercellular lipids including, ceramides, free sterols and sterolesters, cholesterolsulfate, and free fatty acids. The stratum corneum continually renews itself, and there is a steady state between the proliferation and differentiation process of keratinocytes and desquamation of corneocytes.

Original languageEnglish
Title of host publicationTextbook of Aging Skin
PublisherSpringer Berlin Heidelberg
Number of pages5
ISBN (Print)9783540896555
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Medicine(all)


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