Corneocyte size and cell renewal: Effects of aging and sex hormones

Enzo Berardesca, Joachim Fluhr

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The stratum corneum is viewed currently as a layer of protein-enriched corneocytes embedded in a lipid-enriched, intercellular matrix [1], the so-called bricks and mortar model. The bricks are corneocytes surrounded by a cornified cell envelope made up of proteins, mainly loricrin, filaggrin, and involucrin, and covalently bound to the hydroxyceramide molecules of a lipid envelope. These bricks are embedded in a mortar of lipid bilayers [2-4]. The so-called mortar contains a variety of intercellular lipids including, ceramides, free sterols and sterolesters, cholesterolsulfate, and free fatty acids. The stratum corneum continually renews itself, and there is a steady state between the proliferation and differentiation process of keratinocytes and desquamation of corneocytes.

Original languageEnglish
Title of host publicationTextbook of Aging Skin
PublisherSpringer Berlin Heidelberg
Pages371-375
Number of pages5
ISBN (Print)9783540896555
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Medicine(all)

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