Abstract
Diabetic and non-diabetic subjects with angina who underwent angiography and were subsequently treated surgically or medically and followed up for 5 years were analysed in order to assess coronary angiographic findings, efficacy of coronary artery bypass grafting and prognostic criteria in Type 2 diabetic patients with angina as compared to non-diabetic subjects. A total of 1853 non-diabetic and 145 diabetic subjects underwent angiography, including respectively 857 and 68 who had surgery. Perioperative mortality, survival, reinfarction and asymptomaticity rates were measured. Multivariate analysis of risk factors and clinical features was performed. Diabetic patients had a higher frequency of multi-vessel stenoses (p <0.001), a greater diffusion of stenoses (p <0.005) and worse left ventricular motion (p <0.005). No differences were found in perioperative infarction and mortality. Operated diabetic patients had a higher survival rate (p <0.001) and a longer symptom-free period (p <0.05) than unoperated diabetic patients. Operated diabetic patients had similar survival and more frequent recurrence of angina (p <0.05) than operated non-diabetic patients. Survival rate was lower for unoperated diabetic patients than unoperated nondiabetic patients (p <0.05). Recurrence of angina was similar. Multivariate analysis did not indicate diabetes as a factor affecting survival. It is concluded that surgery for Type 2 diabetic patients with coronary artery disease is a suitable therapeutic option conferring a reduction in mortality regardless of the presence of diabetes.
| Original language | English |
|---|---|
| Pages (from-to) | 420-427 |
| Number of pages | 8 |
| Journal | Diabete et Metabolisme |
| Volume | 21 |
| Issue number | 6 |
| Publication status | Published - 1995 |
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Keywords
- angina
- aorto-coronary by-pass grafting
- cardiac mortality
- coronary angiography
- type 2 diabetes (NIDDM)
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Coronary angiography and aorto-coronary bypass surgery in type 2 diabetic patients. / Faglia, E.; Favales, F.; Brivio, M.; Pizzi, G. L.; Campolo, L.; Cataldo, G.; Pirelli, S.; Pellegrini, A.; Taglieri, C.; Caroli, A.
In: Diabete et Metabolisme, Vol. 21, No. 6, 1995, p. 420-427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coronary angiography and aorto-coronary bypass surgery in type 2 diabetic patients
AU - Faglia, E.
AU - Favales, F.
AU - Brivio, M.
AU - Pizzi, G. L.
AU - Campolo, L.
AU - Cataldo, G.
AU - Pirelli, S.
AU - Pellegrini, A.
AU - Taglieri, C.
AU - Caroli, A.
PY - 1995
Y1 - 1995
N2 - Diabetic and non-diabetic subjects with angina who underwent angiography and were subsequently treated surgically or medically and followed up for 5 years were analysed in order to assess coronary angiographic findings, efficacy of coronary artery bypass grafting and prognostic criteria in Type 2 diabetic patients with angina as compared to non-diabetic subjects. A total of 1853 non-diabetic and 145 diabetic subjects underwent angiography, including respectively 857 and 68 who had surgery. Perioperative mortality, survival, reinfarction and asymptomaticity rates were measured. Multivariate analysis of risk factors and clinical features was performed. Diabetic patients had a higher frequency of multi-vessel stenoses (p <0.001), a greater diffusion of stenoses (p <0.005) and worse left ventricular motion (p <0.005). No differences were found in perioperative infarction and mortality. Operated diabetic patients had a higher survival rate (p <0.001) and a longer symptom-free period (p <0.05) than unoperated diabetic patients. Operated diabetic patients had similar survival and more frequent recurrence of angina (p <0.05) than operated non-diabetic patients. Survival rate was lower for unoperated diabetic patients than unoperated nondiabetic patients (p <0.05). Recurrence of angina was similar. Multivariate analysis did not indicate diabetes as a factor affecting survival. It is concluded that surgery for Type 2 diabetic patients with coronary artery disease is a suitable therapeutic option conferring a reduction in mortality regardless of the presence of diabetes.
AB - Diabetic and non-diabetic subjects with angina who underwent angiography and were subsequently treated surgically or medically and followed up for 5 years were analysed in order to assess coronary angiographic findings, efficacy of coronary artery bypass grafting and prognostic criteria in Type 2 diabetic patients with angina as compared to non-diabetic subjects. A total of 1853 non-diabetic and 145 diabetic subjects underwent angiography, including respectively 857 and 68 who had surgery. Perioperative mortality, survival, reinfarction and asymptomaticity rates were measured. Multivariate analysis of risk factors and clinical features was performed. Diabetic patients had a higher frequency of multi-vessel stenoses (p <0.001), a greater diffusion of stenoses (p <0.005) and worse left ventricular motion (p <0.005). No differences were found in perioperative infarction and mortality. Operated diabetic patients had a higher survival rate (p <0.001) and a longer symptom-free period (p <0.05) than unoperated diabetic patients. Operated diabetic patients had similar survival and more frequent recurrence of angina (p <0.05) than operated non-diabetic patients. Survival rate was lower for unoperated diabetic patients than unoperated nondiabetic patients (p <0.05). Recurrence of angina was similar. Multivariate analysis did not indicate diabetes as a factor affecting survival. It is concluded that surgery for Type 2 diabetic patients with coronary artery disease is a suitable therapeutic option conferring a reduction in mortality regardless of the presence of diabetes.
KW - angina
KW - aorto-coronary by-pass grafting
KW - cardiac mortality
KW - coronary angiography
KW - type 2 diabetes (NIDDM)
UR - http://www.scopus.com/inward/record.url?scp=0029560669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029560669&partnerID=8YFLogxK
M3 - Article
C2 - 8593923
AN - SCOPUS:0029560669
VL - 21
SP - 420
EP - 427
JO - Diabetes and Metabolism
JF - Diabetes and Metabolism
SN - 1262-3636
IS - 6
ER -