Coronary artery bypass grafting for Fabry's disease: veins more suitable than arteries?

Cristina Chimenti, Emanuela Morgante, Giuseppe Critelli, Matteo A. Russo, Andrea Frustaci

Research output: Contribution to journalArticle

Abstract

Coronary artery bypass grafting was performed in a 54-year-old man affected by untreated Fabry's disease. Left internal mammary artery (LIMA) and saphenous vein grafts were implanted. Surgical samples of LIMA revealed diffuse glycosphyngolipid infiltration of smooth muscle cells, whereas SV was normal. After surgery, the patient received antithrombotic and enzyme replacement therapy. At 1-year follow-up, LIMA graft occluded, whereas saphenous vein graft remained patent. In Fabry's disease, veins, probably because of a low pressure load, seem to be spared from glycosphingolipid accumulation and are more suitable than arteries for grafting. A preventive histology of conduits is suggested before graft selection.

Original languageEnglish
Pages (from-to)1864-1867
Number of pages4
JournalHuman Pathology
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Coronary artery bypass grafting
  • Enzyme replacement therapy
  • Fabry's disease
  • Left internal mammary artery
  • Saphenous vein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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