Coronary artery disease and depression: Possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms

Sara Bozzini, Patrick Gambelli, Chiara Boiocchi, Sandra Schirinzi, Rossana Falcone, Paola Buzzi, Cesare Storti, Colomba Falcone

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) and depression are two of the most common human health problems. Patients with depression have an increased risk of developing cardiovascular disease and mortality after experiencing a cardiac event. Both diseases are complex disorders that are influenced by genetic and environmental factors. Brain-derived neurotrophic factor (BDNF) plays a critical role in regulating both vascular development and response to injury, and promotes survival, differentiation, and maintenance of neurons in the peripheral and nervous system. Evidence suggests that BDNF can enhance serotoninergic transmission. Serotonin modulates different brain functions and is known to regulate sleep, appetite, pain and inflammation. The aims of the present case-control study were to investigate the possible role of BDNF Val66Met, 5-HTTLPR and -1438 G/A polymorphisms in the development of coronary artery disease (CAD) in patients with and without depression. Regarding BDNF, our data suggest an involvement of the AA genotype in the pathogenesis of CAD in females and in the predisposition to CAD associated with depression. Furthermore, it could be argued that the GG genotype is protective against CAD in the female population and against CAD associated with depression. In our CAD population we also observed a significant increase in the L/L genotype and a decrease in the S/L genotype with respect to the controls. A higher frequency of the L allele, responsible for enhancing the efficiency of transcription, was found in CAD patients. These findings may be responsible for the increased capacity of platelet serotonin uptake previously observed in patients with CAD. Although no differences were found for genotype and allelic frequencies of the -1438 G/A polymorphism between the CAD patients and controls, we cannot exclude the possible role of this receptor in coronary artery disease.

Original languageEnglish
Pages (from-to)813-818
Number of pages6
JournalInternational Journal of Molecular Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Brain-Derived Neurotrophic Factor
Coronary Artery Disease
Depression
Genes
Genotype
Serotonin
Cardiovascular Diseases
Inborn Genetic Diseases
Peripheral Nervous System
Appetite
Gene Frequency
Population
Blood Vessels
Case-Control Studies
Sleep
Blood Platelets
Maintenance
Inflammation
Neurons

Keywords

  • Brain-derived neurotrophic factor
  • Coronary artery disease
  • Depression
  • DNA polymorphisms
  • Serotonin

ASJC Scopus subject areas

  • Genetics

Cite this

Coronary artery disease and depression : Possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms. / Bozzini, Sara; Gambelli, Patrick; Boiocchi, Chiara; Schirinzi, Sandra; Falcone, Rossana; Buzzi, Paola; Storti, Cesare; Falcone, Colomba.

In: International Journal of Molecular Medicine, Vol. 24, No. 6, 2009, p. 813-818.

Research output: Contribution to journalArticle

Bozzini, Sara ; Gambelli, Patrick ; Boiocchi, Chiara ; Schirinzi, Sandra ; Falcone, Rossana ; Buzzi, Paola ; Storti, Cesare ; Falcone, Colomba. / Coronary artery disease and depression : Possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms. In: International Journal of Molecular Medicine. 2009 ; Vol. 24, No. 6. pp. 813-818.
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