TY - JOUR
T1 - Coronary artery disease and type 2 diabetes: A proteomic study
AU - Ferrannini, Giulia
AU - Manca, Maria Laura
AU - Magnoni, Marco
AU - Andreotti, Felicita
AU - Andreini, Daniele
AU - Latini, Roberto
AU - Maseri, Attilio
AU - Maggioni, Aldo P.
AU - Ostroff, Rachel M.
AU - Williams, Stephen A.
AU - Ferrannini, Ele
N1 - Funding Information:
Funding. Funding was provided by the Heart Care Foundation of the Italian Association of Hospital Cardiologists, Florence, Italy. Duality of Interest. F.A. reports receiving consultancy/speaker fees from Amgen, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb/ Pfizer, and Daiichi Sankyo. A.P.M. reports receiving fees, outside the present work, from Bayer, Fresenius, and Novartis for participation in study committees. R.M.O. and S.A.W. are employeesofSomaLogicInc.E.F.reportsreceiving consultancy/speaker fees, outside the present work, from Boehringer Ingelheim, Eli Lilly, Astra-Zeneca, and Sanofi. No other potential conflicts of interest relevant to this article were reported.
Publisher Copyright:
© 2020 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluationda cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD2 (clean coronaries) and CAD1 (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD. RESULTS Though CAD1 was more prevalent among participants with T2D (HbA1c 6.7 6 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were “protected” from CAD if female (P 5 0.007), younger (P 5 0.021), and with lower renin levels (P 5 0.02). CONCLUSIONS We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.
AB - OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluationda cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD2 (clean coronaries) and CAD1 (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD. RESULTS Though CAD1 was more prevalent among participants with T2D (HbA1c 6.7 6 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were “protected” from CAD if female (P 5 0.007), younger (P 5 0.021), and with lower renin levels (P 5 0.02). CONCLUSIONS We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD.
UR - http://www.scopus.com/inward/record.url?scp=85082148053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082148053&partnerID=8YFLogxK
U2 - 10.2337/dc19-1902
DO - 10.2337/dc19-1902
M3 - Article
C2 - 31988066
AN - SCOPUS:85082148053
VL - 43
SP - 843
EP - 851
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 4
ER -