Cardiovascular diseases are the main cause of death of renal transplanted patients (pts): among these, ischaemic heart disease is very common, even its real prevalence is not well defined. We have though evaluated within 90 pts the confirmation of symptomatic coronary artery disease (CAD), and screened 48 asymptomatic pts for the detection of silent ischaemia (SI). Fourteen pts (15.6%) showed a picture of CAD, in 43% of the cases with a multi-vessels disease. Four pts underwent angioplasty, 2 coronary by-passes, successfully and without worsening of renal function. Among risk factors we depicted cigarette smoking, previously diagnosed EKG T wave abnormalities, and Cyclosporine A (CyA) posology, this latter regardless of treatment schedules used. Concerning SI, 4.1% of the pts investigated with an exercise-induced stress test and 22% of those with myocardial scintigraphy had an angiogram positive for CAD. In conclusion it seems worthy to pay more attention to the detection of CAD considering its prevalence, the absence of main side-effects related to the use of contrast media or complex diagnostic procedures and the good results obtained with medical or surgical therapies. If CyA should be confirmed as related to ischaemic disease, it will be necessary to evaluate alternative immunosuppressive drug regimens.
|Translated title of the contribution||Coronary artery disease in renal transplant patients|
|Number of pages||7|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1995|
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