Coronary atherosclerosis and adverse outcomes in patients with recent-onset atrial fibrillation and troponin rise

Alberto Conti, Elena Angeli, Margherita Scorpiniti, Andrea Alesi, Federica Trausi, Delia Lazzeretti, Luigi Padeletti, Gian Franco Gensini

Research output: Contribution to journalArticle

Abstract

Background The relationship between troponin and atrial fibrillation (AF) without acute coronary syndrome is still unclear. We sought to investigate the presence of coronary atherosclerosis and adverse outcomes in patients with AF. Methods Consecutive patients with recent-onset AF and without severe comorbidities were enrolled between 2004 and 2013. Patients with a troponin rise or with adverse outcomes were considered for coronary angiography and revascularization when "critical" stenosis (≥ 70%) was recognized. Propensity score matching was performed to adjust for baseline characteristics; after matching, no differences existed between the groups of patients with or without troponin rise. The primary end point was the composite of acute coronary syndrome, revascularization, and cardiac death at 1- and 12-month follow-ups. Results Of 3627 patients enrolled, 3541 completed the study; 202 (6%) showed troponin rise; and 91 (3%), an adverse outcome. In the entire cohort, on multivariate analysis, the odds ratio for the occurrence of the primary end point of troponin rise was 14 (95% confidence interval [CI], 10-23; P

Original languageEnglish
Pages (from-to)1407-1413
Number of pages7
JournalAmerican Journal of Emergency Medicine
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

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Troponin
Atrial Fibrillation
Coronary Artery Disease
Acute Coronary Syndrome
Propensity Score
Coronary Angiography
Comorbidity
Pathologic Constriction
Multivariate Analysis
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Emergency Medicine
  • Medicine(all)

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Coronary atherosclerosis and adverse outcomes in patients with recent-onset atrial fibrillation and troponin rise. / Conti, Alberto; Angeli, Elena; Scorpiniti, Margherita; Alesi, Andrea; Trausi, Federica; Lazzeretti, Delia; Padeletti, Luigi; Gensini, Gian Franco.

In: American Journal of Emergency Medicine, Vol. 33, No. 10, 01.10.2015, p. 1407-1413.

Research output: Contribution to journalArticle

Conti, A, Angeli, E, Scorpiniti, M, Alesi, A, Trausi, F, Lazzeretti, D, Padeletti, L & Gensini, GF 2015, 'Coronary atherosclerosis and adverse outcomes in patients with recent-onset atrial fibrillation and troponin rise', American Journal of Emergency Medicine, vol. 33, no. 10, pp. 1407-1413. https://doi.org/10.1016/j.ajem.2015.07.013
Conti, Alberto ; Angeli, Elena ; Scorpiniti, Margherita ; Alesi, Andrea ; Trausi, Federica ; Lazzeretti, Delia ; Padeletti, Luigi ; Gensini, Gian Franco. / Coronary atherosclerosis and adverse outcomes in patients with recent-onset atrial fibrillation and troponin rise. In: American Journal of Emergency Medicine. 2015 ; Vol. 33, No. 10. pp. 1407-1413.
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AU - Scorpiniti, Margherita

AU - Alesi, Andrea

AU - Trausi, Federica

AU - Lazzeretti, Delia

AU - Padeletti, Luigi

AU - Gensini, Gian Franco

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AB - Background The relationship between troponin and atrial fibrillation (AF) without acute coronary syndrome is still unclear. We sought to investigate the presence of coronary atherosclerosis and adverse outcomes in patients with AF. Methods Consecutive patients with recent-onset AF and without severe comorbidities were enrolled between 2004 and 2013. Patients with a troponin rise or with adverse outcomes were considered for coronary angiography and revascularization when "critical" stenosis (≥ 70%) was recognized. Propensity score matching was performed to adjust for baseline characteristics; after matching, no differences existed between the groups of patients with or without troponin rise. The primary end point was the composite of acute coronary syndrome, revascularization, and cardiac death at 1- and 12-month follow-ups. Results Of 3627 patients enrolled, 3541 completed the study; 202 (6%) showed troponin rise; and 91 (3%), an adverse outcome. In the entire cohort, on multivariate analysis, the odds ratio for the occurrence of the primary end point of troponin rise was 14 (95% confidence interval [CI], 10-23; P

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