Coronary bioresorbable vascular scaffold use in the treatment of coronary artery disease

Luca Testa, Azeem Latib, Rocco A. Montone, Antonio Colombo, Francesco Bedogni

Research output: Contribution to journalReview article

Abstract

Bioresorbable vascular scaffolds (BVS) represent a promising novel approach for the treatment of coronary artery disease. BVS promise to address some of the well-known limitations of current drug-eluting stents, while providing a transient scaffolding of the vessel to prevent acute vessel closure/recoil. Drug elution by BVS prevents neointimal proliferation in a similar fashion to drug-eluting stents, and complete bioresorption is associated with late vessel lumen enlargement, plaque regression, and restoration of vasomotion. Based on the pathophysiological reasons and on the results derived from clinical studies, BVS are increasingly being used in clinical practice. The aim of this review is to provide an overview of the current evidence supporting the use of BVS in clinical practice. In particular, we will discuss the randomized controlled trials and registries evaluating the clinical outcome of these devices, with a special focus on their application in patients with acute coronary syndrome and in specific lesion subsets (bifurcations, chronic total occlusions, and in-stent restenosis).

Original languageEnglish
JournalCirculation: Cardiovascular Interventions
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Blood Vessels
Coronary Artery Disease
Drug-Eluting Stents
Therapeutics
Acute Coronary Syndrome
Stents
Registries
Randomized Controlled Trials
Equipment and Supplies
Pharmaceutical Preparations

Keywords

  • biodegradable polymers
  • bioresorbable vascular scaffold
  • coronary artery disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Coronary bioresorbable vascular scaffold use in the treatment of coronary artery disease. / Testa, Luca; Latib, Azeem; Montone, Rocco A.; Colombo, Antonio; Bedogni, Francesco.

In: Circulation: Cardiovascular Interventions, Vol. 9, No. 7, 01.07.2016.

Research output: Contribution to journalReview article

@article{3d756c58f5274b079fde3eb4e3c030b1,
title = "Coronary bioresorbable vascular scaffold use in the treatment of coronary artery disease",
abstract = "Bioresorbable vascular scaffolds (BVS) represent a promising novel approach for the treatment of coronary artery disease. BVS promise to address some of the well-known limitations of current drug-eluting stents, while providing a transient scaffolding of the vessel to prevent acute vessel closure/recoil. Drug elution by BVS prevents neointimal proliferation in a similar fashion to drug-eluting stents, and complete bioresorption is associated with late vessel lumen enlargement, plaque regression, and restoration of vasomotion. Based on the pathophysiological reasons and on the results derived from clinical studies, BVS are increasingly being used in clinical practice. The aim of this review is to provide an overview of the current evidence supporting the use of BVS in clinical practice. In particular, we will discuss the randomized controlled trials and registries evaluating the clinical outcome of these devices, with a special focus on their application in patients with acute coronary syndrome and in specific lesion subsets (bifurcations, chronic total occlusions, and in-stent restenosis).",
keywords = "biodegradable polymers, bioresorbable vascular scaffold, coronary artery disease",
author = "Luca Testa and Azeem Latib and Montone, {Rocco A.} and Antonio Colombo and Francesco Bedogni",
year = "2016",
month = "7",
day = "1",
doi = "10.1161/CIRCINTERVENTIONS.116.003978",
language = "English",
volume = "9",
journal = "Circulation: Cardiovascular Interventions",
issn = "1941-7640",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Coronary bioresorbable vascular scaffold use in the treatment of coronary artery disease

AU - Testa, Luca

AU - Latib, Azeem

AU - Montone, Rocco A.

AU - Colombo, Antonio

AU - Bedogni, Francesco

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Bioresorbable vascular scaffolds (BVS) represent a promising novel approach for the treatment of coronary artery disease. BVS promise to address some of the well-known limitations of current drug-eluting stents, while providing a transient scaffolding of the vessel to prevent acute vessel closure/recoil. Drug elution by BVS prevents neointimal proliferation in a similar fashion to drug-eluting stents, and complete bioresorption is associated with late vessel lumen enlargement, plaque regression, and restoration of vasomotion. Based on the pathophysiological reasons and on the results derived from clinical studies, BVS are increasingly being used in clinical practice. The aim of this review is to provide an overview of the current evidence supporting the use of BVS in clinical practice. In particular, we will discuss the randomized controlled trials and registries evaluating the clinical outcome of these devices, with a special focus on their application in patients with acute coronary syndrome and in specific lesion subsets (bifurcations, chronic total occlusions, and in-stent restenosis).

AB - Bioresorbable vascular scaffolds (BVS) represent a promising novel approach for the treatment of coronary artery disease. BVS promise to address some of the well-known limitations of current drug-eluting stents, while providing a transient scaffolding of the vessel to prevent acute vessel closure/recoil. Drug elution by BVS prevents neointimal proliferation in a similar fashion to drug-eluting stents, and complete bioresorption is associated with late vessel lumen enlargement, plaque regression, and restoration of vasomotion. Based on the pathophysiological reasons and on the results derived from clinical studies, BVS are increasingly being used in clinical practice. The aim of this review is to provide an overview of the current evidence supporting the use of BVS in clinical practice. In particular, we will discuss the randomized controlled trials and registries evaluating the clinical outcome of these devices, with a special focus on their application in patients with acute coronary syndrome and in specific lesion subsets (bifurcations, chronic total occlusions, and in-stent restenosis).

KW - biodegradable polymers

KW - bioresorbable vascular scaffold

KW - coronary artery disease

UR - http://www.scopus.com/inward/record.url?scp=84978877741&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978877741&partnerID=8YFLogxK

U2 - 10.1161/CIRCINTERVENTIONS.116.003978

DO - 10.1161/CIRCINTERVENTIONS.116.003978

M3 - Review article

AN - SCOPUS:84978877741

VL - 9

JO - Circulation: Cardiovascular Interventions

JF - Circulation: Cardiovascular Interventions

SN - 1941-7640

IS - 7

ER -