Coronary computed tomography: Current role and future perspectives for cardiovascular risk stratification

Pasquale Perrone-Filardi, Francesca Musella, Gianluigi Savarese, Milena Cecere, Caterina Marciano, Oriana Scala, Giuseppe Rengo, Santo Dellegrottaglie, Alberto Cuocolo, Dario Leosco

Research output: Contribution to journalArticlepeer-review


Coronary artery disease (CAD) is the major cause of morbidity and mortality worldwide. More than 50% of CAD deaths occur in previously asymptomatic individuals at intermediate cardiovascular risk, highlighting the need of more accurate individual risk assessment to decrease cardiovascular events. Cardiac computed tomography (CCT) has emerged as a valuable technique for risk stratification in asymptomatic subjects and in symptomatic patients without known CAD. The absence of coronary artery calcium (CAC) identifies asymptomatic subjects at very low cardiac risk and is reasonable in intermediate risk individuals, in whom CAC measurement reclassifies a substantial number of subjects to different risk categories. In symptomatic patients with suspected CAD, detection of non-obstructive or obstructive CAD by CCT angiography is associated with increased all-cause mortality, and provides incremental risk stratification to CAC. Further studies are needed to assess the impact of CCT on clinical outcomes and its cost-effectiveness in different clinical settings. Published on behalf of the European Society of Cardiology. All rights reserved.

Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalEuropean Heart Journal Cardiovascular Imaging
Issue number6
Publication statusPublished - Jun 2012


  • Cardiovascular imaging
  • Cardiovascular risk
  • Coronary artery disease
  • Coronary calcium score
  • Coronary CT angiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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