TY - JOUR
T1 - Coronary computed tomography
T2 - Current role and future perspectives for cardiovascular risk stratification
AU - Perrone-Filardi, Pasquale
AU - Musella, Francesca
AU - Savarese, Gianluigi
AU - Cecere, Milena
AU - Marciano, Caterina
AU - Scala, Oriana
AU - Rengo, Giuseppe
AU - Dellegrottaglie, Santo
AU - Cuocolo, Alberto
AU - Leosco, Dario
PY - 2012/6
Y1 - 2012/6
N2 - Coronary artery disease (CAD) is the major cause of morbidity and mortality worldwide. More than 50% of CAD deaths occur in previously asymptomatic individuals at intermediate cardiovascular risk, highlighting the need of more accurate individual risk assessment to decrease cardiovascular events. Cardiac computed tomography (CCT) has emerged as a valuable technique for risk stratification in asymptomatic subjects and in symptomatic patients without known CAD. The absence of coronary artery calcium (CAC) identifies asymptomatic subjects at very low cardiac risk and is reasonable in intermediate risk individuals, in whom CAC measurement reclassifies a substantial number of subjects to different risk categories. In symptomatic patients with suspected CAD, detection of non-obstructive or obstructive CAD by CCT angiography is associated with increased all-cause mortality, and provides incremental risk stratification to CAC. Further studies are needed to assess the impact of CCT on clinical outcomes and its cost-effectiveness in different clinical settings. Published on behalf of the European Society of Cardiology. All rights reserved.
AB - Coronary artery disease (CAD) is the major cause of morbidity and mortality worldwide. More than 50% of CAD deaths occur in previously asymptomatic individuals at intermediate cardiovascular risk, highlighting the need of more accurate individual risk assessment to decrease cardiovascular events. Cardiac computed tomography (CCT) has emerged as a valuable technique for risk stratification in asymptomatic subjects and in symptomatic patients without known CAD. The absence of coronary artery calcium (CAC) identifies asymptomatic subjects at very low cardiac risk and is reasonable in intermediate risk individuals, in whom CAC measurement reclassifies a substantial number of subjects to different risk categories. In symptomatic patients with suspected CAD, detection of non-obstructive or obstructive CAD by CCT angiography is associated with increased all-cause mortality, and provides incremental risk stratification to CAC. Further studies are needed to assess the impact of CCT on clinical outcomes and its cost-effectiveness in different clinical settings. Published on behalf of the European Society of Cardiology. All rights reserved.
KW - Cardiovascular imaging
KW - Cardiovascular risk
KW - Coronary artery disease
KW - Coronary calcium score
KW - Coronary CT angiography
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U2 - 10.1093/ehjci/jes081
DO - 10.1093/ehjci/jes081
M3 - Article
C2 - 22523008
AN - SCOPUS:84863846068
VL - 13
SP - 453
EP - 458
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 6
ER -