Abstract
Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P
Original language | English |
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Pages (from-to) | 1233-1238 |
Number of pages | 6 |
Journal | Circulation |
Volume | 102 |
Issue number | 11 |
Publication status | Published - Sep 12 2000 |
Keywords
- Blood flow
- Circulation
- Coronary arteries
- Smoking
- Tomography
- Vitamins
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine