Coronary heart desease in smokers: Vitamin C restores coronary microcirculatory function

Philipp A. Kaufmann, Tomaso Gnecchi-Ruscone, Marco Di Terlizzi, Klaus P. Schäfers, Thomas F. Lüscher, Paolo G. Camici

Research output: Contribution to journalArticlepeer-review


Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P

Original languageEnglish
Pages (from-to)1233-1238
Number of pages6
Issue number11
Publication statusPublished - Sep 12 2000


  • Blood flow
  • Circulation
  • Coronary arteries
  • Smoking
  • Tomography
  • Vitamins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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