Coronary heart desease in smokers: Vitamin C restores coronary microcirculatory function

Philipp A. Kaufmann; Tomaso Gnecchi-Ruscone; Marco Di Terlizzi; Klaus P. Schäfers; Thomas F. Lüscher; Paolo G. Camici

Coronary heart desease in smokers: Vitamin C restores coronary microcirculatory function

Philipp A. Kaufmann, Tomaso Gnecchi-Ruscone, Marco Di Terlizzi, Klaus P. Schäfers, Thomas F. Lüscher, Paolo G. Camici

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P

Original language	English
Pages (from-to)	1233-1238
Number of pages	6
Journal	Circulation
Volume	102
Issue number	11
Publication status	Published - Sep 12 2000

Keywords

Blood flow
Circulation
Coronary arteries
Smoking
Tomography
Vitamins

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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title = "Coronary heart desease in smokers: Vitamin C restores coronary microcirculatory function",

abstract = "Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P",

keywords = "Blood flow, Circulation, Coronary arteries, Smoking, Tomography, Vitamins",

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T2 - Vitamin C restores coronary microcirculatory function

AU - Kaufmann, Philipp A.

AU - Gnecchi-Ruscone, Tomaso

AU - Di Terlizzi, Marco

AU - Schäfers, Klaus P.

AU - Lüscher, Thomas F.

AU - Camici, Paolo G.

PY - 2000/9/12

Y1 - 2000/9/12

N2 - Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P

AB - Background - Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress. Methods and Results - We used positron emission tomography to measure the coronary flow reserve, an integrated measure of coronary flow, through both the large epicardial coronary arteries and the microcirculation in 11 smokers and 8 control subjects before and after administration of the antioxidant vitamin C. At baseline, coronary flow reserve was reduced by 21% in smokers compared with control subjects (P

KW - Blood flow

KW - Circulation

KW - Coronary arteries

KW - Smoking

KW - Tomography

KW - Vitamins

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