Coronary heart disease in postmenopausal women with type II diabetes mellitus and the impact of estrogen replacement therapy: A narrative review

Marouane Boukhris, Salvatore Davide Tomasello, Francesco Marzà, Sonia Bregante, Francesca Romana Pluchinotta, Alfredo Ruggero Galassi

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Abstract

Coronary heart disease is the main cause of death in postmenopausal women (PMW); moreover its mortality exceeds those for breast cancer in women at all ages. Type II diabetes mellitus is a major cardiovascular risk factor and there is some evidence that the risk conferred by diabetes is greater in women than in men. It was established that the deficiency of endogenous estrogens promotes the atherosclerosis process. However, the impact of estrogen replacement therapy (ERT) on cardiovascular prevention remains controversial. Some authors strongly recommend it, whereas others revealed a concerning trend toward harm. This review tries to underlines the different components of cardiovascular risk in diabetic PMW and to define the place of ERT.

Original languageEnglish
Article number413920
JournalInternational Journal of Endocrinology
Volume2014
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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