Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy

Franco Cecchi, Iacopo Olivotto, Roberto Gistri, Roberto Lorenzoni, Giampaolo Chiriatti, Paolo G. Camici

Research output: Contribution to journalArticlepeer-review


BACKCROUND: Microvascular dysfunction, reflected by an inadequate increase in myocardial blood flow in response to dipyridamole infusion, is a recognized feature of hypertrophic cardiomyopathy. Its long-term effect on the prognosis is unknown. We prospectively evaluated a cohort of patients with hypertrophic cardiomyopathy after they had undergone quantitative assessment of myocardial blood flow by positron-emission tomography (PET). METHODS: Fifty-one patients (New York Heart Association class I or II) were followed for a mean (±SD) of 8.1±2.1 years after PET. Twelve subjects with atypical chest pain served as controls. Measurement of flow was performed at base line and after the infusion of the coronary vasodilator dipyridamole, with the use of nitrogen-13-labeled ammonia. Patients were then divided into three equal groups with increasing values of myocardial blood flow. RESULTS: The response of myocardial blood flow to dipyridamole was severely blunted in the patients, as compared with the controls (1.50±0.69 vs. 2.71±0.94 ml per minute per gram of tissue, P

Original languageEnglish
Pages (from-to)1027-1035
Number of pages9
JournalNew England Journal of Medicine
Issue number11
Publication statusPublished - Sep 11 2003

ASJC Scopus subject areas

  • Medicine(all)


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