Coronary microvascular dysfunction in asymptomatic patients affected by systemic sclerosis: Limited vs. diffuse form

Alessia Faccini, Eustachio Agricola, Michele Oppizzi, Alberto Margonato, Maurizio Galderisi, Maria Grazia Sabbadini, Stefano Franchini, Paolo G. Camici

Research output: Contribution to journalArticlepeer-review

Abstract

Background: This observational study was designed to evaluate the prevalence of coronary microvascular dysfunction (CMD) in asymptomatic patients affected by systemic sclerosis (SSc), stratifying the results according to the limited (lcSSc) and the diffuse (dcSSc) forms of the disease. Methods and Results: We enrolled 19 consecutive asymptomatic patients with dcSSc (n=7) or lcSSc (n=12). In all subjects, coronary flow reserve (CFR) was assessed by measuring diastolic coronary flow velocities in the left anterior descending artery by pulsed wave Doppler at baseline and after dipyridamole infusion (0.84 mg ・ kg 1 ・ 6 min 1). Wall motion score index was evaluated at baseline and during stress. We enrolled 20 healthy subjects as controls. Mean CFR was 1.96 ± 0.62 in patients and 2.69 ± 0.47 in controls (P

Original languageEnglish
Pages (from-to)825-829
Number of pages5
JournalCirculation Journal
Volume79
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Asymptomatic heart involvement
  • Coronary microvascular dysfunction
  • Stress echocardiography
  • Systemic sclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Coronary microvascular dysfunction in asymptomatic patients affected by systemic sclerosis: Limited vs. diffuse form'. Together they form a unique fingerprint.

Cite this