Coronary microvascular function and cortical pain processing in patients with silent positive exercise testing and normal coronary arteries

Antonino Di Franco, Gaetano A. Lanza, Antonio Di Monaco, Alfonso Sestito, Priscilla Lamendola, Roberto Nerla, Pierpaolo Tarzia, Daniela Virdis, Catello Vollono, Massimiliano Valeriani, Filippo Crea

Research output: Contribution to journalArticlepeer-review

Abstract

ST-segment depression during exercise stress testing in asymptomatic subjects showing normal coronary arteries is considered a "false- positive" result. Coronary microvascular dysfunction, however, might be a possible cause of ST-segment depression in these cases. We assessed the coronary blood flow response to adenosine and to cold pressor test in the left anterior descending artery, using transthoracic Doppler echocardiography in 14 asymptomatic subjects with exercise-induced ST-segment depression and normal coronary arteries (group 1), 14 patients with microvascular angina (group 2), and 14 healthy subjects (group 3). Flow-mediated dilation was assessed in the brachial artery. Central pain processing was assessed using cortical laser evoked potentials during chest and right hand stimulation with 3 sequences of painful stimuli. The coronary blood flow response to adenosine was 1.8 ± 0.4, 1.9 ± 0.5, and 3.1 ± 0.9 in groups 1, 2, and 3, respectively (p

Original languageEnglish
Pages (from-to)1705-1710
Number of pages6
JournalThe American Journal of Cardiology
Volume109
Issue number12
DOIs
Publication statusPublished - Jun 15 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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