Coronary microvascular resistance: Methods for its quantification in humans

Paul Knaapen, Paolo G. Camici, Koen M. Marques, Robin Nijveldt, Jeroen J. Bax, Nico Westerhof, Marco J W Götte, Michael Jerosch-Herold, Heinrich R. Schelbert, Adriaan A. Lammertsma, Albert C. van Rossum

Research output: Contribution to journalArticle

Abstract

Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses.

Original languageEnglish
Pages (from-to)485-498
Number of pages14
JournalBasic Research in Cardiology
Volume104
Issue number5
DOIs
Publication statusPublished - 2009

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Keywords

  • Coronary microvascular resistance
  • Imaging
  • Perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

Cite this

Knaapen, P., Camici, P. G., Marques, K. M., Nijveldt, R., Bax, J. J., Westerhof, N., Götte, M. J. W., Jerosch-Herold, M., Schelbert, H. R., Lammertsma, A. A., & van Rossum, A. C. (2009). Coronary microvascular resistance: Methods for its quantification in humans. Basic Research in Cardiology, 104(5), 485-498. https://doi.org/10.1007/s00395-009-0037-z