Coronary Protection to Prevent Coronary Obstruction During TAVR: A Multicenter International Registry

Tullio Palmerini, Tarun Chakravarty, Francesco Saia, Antonio G. Bruno, Maria Letizia Bacchi-Reggiani, Cinzia Marrozzini, Chinar Patel, Vivek Patel, Luca Testa, Francesco Bedogni, Marco Ancona, Matteo Montorfano, Alaide Chieffo, Paolo Olivares, Antonio L. Bartorelli, Angelo Buscaglia, Italo Porto, Georg Nickenig, Eberhard Grube, Jan Malte SinningMarco De Carlo, Anna Sonia Petronio, Marco Barbanti, Corrado Tamburino, Alessandro Iadanza, Francesco Burzotta, Carlo Trani, Chiara Fraccaro, Giuseppe Tarantini, Tiziana C. Aranzulla, Mauro De Benedictis, Paolo Pagnotta, Giulio G. Stefanini, Mizuki Miura, Maurizio Taramasso, Jee Hoon Kang, Hyo Soo Kim, Pablo Codner, Ran Kornowski, Francesco Pelliccia, Luigi Vignali, Nevio Taglieri, Gabriele Ghetti, Alessandro Leone, Nazzareno Galiè, Raj Makkar

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of this study was to investigate the safety and efficacy of coronary protection by preventive coronary wiring and stenting across the coronary ostia in patients at high risk for coronary obstruction after transcatheter aortic valve replacement (TAVR). Background: Coronary obstruction following TAVR is a life-threatening complication with high procedural and short-term mortality. Methods: Data were collected retrospectively from a multicenter international registry between April 2011 and February 2019. Results: Among 236 patients undergoing coronary protection with preventive coronary wiring, 143 had eventually stents implanted across the coronary ostia after valve deployment. At 3-year follow-up, rates of cardiac death were 7.8% in patients receiving stents and 15.7% in those not receiving stents (adjusted hazard ratio: 0.42; 95% confidence interval: 0.14 to 1.28; p = 0.13). There were 2 definite stent thromboses (0.9%) in patients receiving stents, both occurring after TAVR in “valve-in-valve” procedures. In patients not receiving stents, there were 4 delayed coronary occlusions (DCOs) (4.3%), occurring from 5 min to 6 h after wire removal. Three cases occurred in valve-in-valve procedures and 1 in a native aortic valve procedure. Distance between the virtual transcatheter valve and the protected coronary ostia <4 mm was present in 75.0% of patients with DCO compared with 30.4% of patients without DCO (p = 0.19). Conclusions: In patients undergoing TAVR at high risk for coronary obstruction, preventive stent implantation across the coronary ostia is associated with good mid-term survival rates and low rates of stent thrombosis. Patients undergoing coronary protection with wire only have a considerable risk for DCO.

Original languageEnglish
Pages (from-to)739-747
Number of pages9
JournalJACC: Cardiovascular Interventions
Issue number6
Publication statusPublished - Mar 23 2020


  • coronary obstruction
  • stent thrombosis
  • transcatheter aortic valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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