Coronary vasoconstriction during myocardial ischemia induced by rises in metabolic demand in patients with coronary artery disease

Gianmario Sambuceti, Mario Marzilli, Paolo Marraccini, Jan Schneider-Eicke, Enri Gliozheni, Oberdan Parodi, Antonio L'Abbate

Research output: Contribution to journalArticle

Abstract

Background: In patients with coronary artery disease, a maximal vasodilation of the coronary microcirculation is generally assumed to occur during myocardial ischemia induced by rises in metabolic demand. However, vasoconstriction has been documented during severe prolonged ischemia in animals. The aim of this study was to investigate coronary vasomotor tone during pacing-induced ischemia in humans. Methods and Results: The study included 11 patients with exercise-induced ischemia and single vessel disease of the left anterior descending artery and 7 control subjects with normal coronary arteries. Blood flow velocity was monitored with a Doppler catheter in the left anterior descending artery. Coronary resistance index was calculated as the ratio between mean arterial pressure and flow velocity. Measurements were obtained at baseline, after intracoronary adenosine (2 mg), and during maximal atrial pacing in the absence and presence of adenosine. After adenosine administration at rest, coronary resistance decreased more in control subjects than in patients (25±7% of baseline versus 61±19%; P

Original languageEnglish
Pages (from-to)2652-2659
Number of pages8
JournalCirculation
Volume95
Issue number12
Publication statusPublished - 1997

Keywords

  • Adenosine
  • Coronary disease
  • Ischemia
  • Vasoconstriction
  • Vasodilation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Sambuceti, G., Marzilli, M., Marraccini, P., Schneider-Eicke, J., Gliozheni, E., Parodi, O., & L'Abbate, A. (1997). Coronary vasoconstriction during myocardial ischemia induced by rises in metabolic demand in patients with coronary artery disease. Circulation, 95(12), 2652-2659.