Coronary vasoconstriction induced by vasopressin: Production of myocardial ischemia in dogs by constriction of nondiseased small vessels

Mary F. Maturi, Sharon E. Martin, David Markle, Maret Maxwell, Cheryl R. Burruss, Edith Speir, Rodney Greene, Young Moo Ro, Dino Vitale, Michael V. Green, Seth R. Goldstein, Stephen L. Bacharach, Randolph E. Patterson

Research output: Contribution to journalArticlepeer-review

Abstract

Background. We studied the effect of intracoronary administration of arginine-8-vasopressin on blood flow in nondiseased coronary arteries and determined whether this vasoconstriction was severe enough to produce ischemia in 30 dogs. Methods and Results. In group 1 (n=6), after vasopressin administration coronary blood flow was decreased by 41% (p

Original languageEnglish
Pages (from-to)2111-2121
Number of pages11
JournalCirculation
Volume83
Issue number6
Publication statusPublished - Jun 1991

Keywords

  • Coronary arteries
  • Cyclooxygenase blockade
  • Ibuprofen
  • Intramyocardial pH
  • Left ventricular ejection fraction
  • Myocardial ischemia
  • Prostaglandins
  • Radionuclide angiography
  • Vasoconstriction
  • Vasopressin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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