Corpse disposal after apoptosis

Patrizia Rovere-Querini, I. E. Dumitriu

Research output: Contribution to journalArticle

Abstract

The termination of the apoptotic program occurs in most cases via recognition and clearance by phagocytes. Engulfed cells do not simply disappear from the midst of living tissues. Constituents of the corpse indeed survive the intracellular processing and are recycled to the membrane of the phagocyte. The presentation of yielded antigens to T cells is a central event in the induction and the maintenance of peripheral tolerance. Conversely, errors in this pathway contribute to the pathogenesis of systemic and organ specific autoimmune diseases. Here we discuss the available information on the events that follow active engulfment of dying cells, with attention to the events involved in vitro and in vivo in apoptotic cell processing. The outcome of the processing is the cross-priming or the functional inactivation of T cells that specifically recognise antigens contained in the cell corpse.

Original languageEnglish
Pages (from-to)469-479
Number of pages11
JournalApoptosis
Volume8
Issue number5
DOIs
Publication statusPublished - Oct 2003

Fingerprint

Cadaver
T-cells
Apoptosis
Phagocytes
Processing
Antigens
Cross-Priming
Peripheral Tolerance
T-Lymphocytes
Antigen Presentation
Cells
Tissue
Autoimmune Diseases
Membranes
Maintenance

Keywords

  • Apoptosis
  • Autoimmunity
  • Cancer
  • Cross-presentation
  • Dendritic cells
  • Phagocytosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Corpse disposal after apoptosis. / Rovere-Querini, Patrizia; Dumitriu, I. E.

In: Apoptosis, Vol. 8, No. 5, 10.2003, p. 469-479.

Research output: Contribution to journalArticle

Rovere-Querini, Patrizia ; Dumitriu, I. E. / Corpse disposal after apoptosis. In: Apoptosis. 2003 ; Vol. 8, No. 5. pp. 469-479.
@article{a489df1ec60a47d38af48be8dfc60166,
title = "Corpse disposal after apoptosis",
abstract = "The termination of the apoptotic program occurs in most cases via recognition and clearance by phagocytes. Engulfed cells do not simply disappear from the midst of living tissues. Constituents of the corpse indeed survive the intracellular processing and are recycled to the membrane of the phagocyte. The presentation of yielded antigens to T cells is a central event in the induction and the maintenance of peripheral tolerance. Conversely, errors in this pathway contribute to the pathogenesis of systemic and organ specific autoimmune diseases. Here we discuss the available information on the events that follow active engulfment of dying cells, with attention to the events involved in vitro and in vivo in apoptotic cell processing. The outcome of the processing is the cross-priming or the functional inactivation of T cells that specifically recognise antigens contained in the cell corpse.",
keywords = "Apoptosis, Autoimmunity, Cancer, Cross-presentation, Dendritic cells, Phagocytosis",
author = "Patrizia Rovere-Querini and Dumitriu, {I. E.}",
year = "2003",
month = "10",
doi = "10.1023/A:1025538324077",
language = "English",
volume = "8",
pages = "469--479",
journal = "Apoptosis : an international journal on programmed cell death",
issn = "1360-8185",
publisher = "Springer Netherlands",
number = "5",

}

TY - JOUR

T1 - Corpse disposal after apoptosis

AU - Rovere-Querini, Patrizia

AU - Dumitriu, I. E.

PY - 2003/10

Y1 - 2003/10

N2 - The termination of the apoptotic program occurs in most cases via recognition and clearance by phagocytes. Engulfed cells do not simply disappear from the midst of living tissues. Constituents of the corpse indeed survive the intracellular processing and are recycled to the membrane of the phagocyte. The presentation of yielded antigens to T cells is a central event in the induction and the maintenance of peripheral tolerance. Conversely, errors in this pathway contribute to the pathogenesis of systemic and organ specific autoimmune diseases. Here we discuss the available information on the events that follow active engulfment of dying cells, with attention to the events involved in vitro and in vivo in apoptotic cell processing. The outcome of the processing is the cross-priming or the functional inactivation of T cells that specifically recognise antigens contained in the cell corpse.

AB - The termination of the apoptotic program occurs in most cases via recognition and clearance by phagocytes. Engulfed cells do not simply disappear from the midst of living tissues. Constituents of the corpse indeed survive the intracellular processing and are recycled to the membrane of the phagocyte. The presentation of yielded antigens to T cells is a central event in the induction and the maintenance of peripheral tolerance. Conversely, errors in this pathway contribute to the pathogenesis of systemic and organ specific autoimmune diseases. Here we discuss the available information on the events that follow active engulfment of dying cells, with attention to the events involved in vitro and in vivo in apoptotic cell processing. The outcome of the processing is the cross-priming or the functional inactivation of T cells that specifically recognise antigens contained in the cell corpse.

KW - Apoptosis

KW - Autoimmunity

KW - Cancer

KW - Cross-presentation

KW - Dendritic cells

KW - Phagocytosis

UR - http://www.scopus.com/inward/record.url?scp=0141927333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141927333&partnerID=8YFLogxK

U2 - 10.1023/A:1025538324077

DO - 10.1023/A:1025538324077

M3 - Article

C2 - 12975578

AN - SCOPUS:0141927333

VL - 8

SP - 469

EP - 479

JO - Apoptosis : an international journal on programmed cell death

JF - Apoptosis : an international journal on programmed cell death

SN - 1360-8185

IS - 5

ER -