Corpus callosum damage and cognitive dysfunction in benign MS

Sarlota Mesaros, Maria A. Rocca, Gianna Riccitelli, Elisabetta Pagani, Marco Rovaris, Domenico Caputo, Angelo Ghezzi, Ruggero Capra, Antonio Bertolotto, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticle

Abstract

Corpus callosum (CC), the largest compact white matter fiber bundle of the human brain involved in interhemispheric transfer, is frequently damaged in the course ofmultiple sclerosis (MS). Cognitive impairment is one of the factors affecting quality of life of patientswith benignMS (BMS). The aimof this study was to investigate the relationship between the cognitive profile of BMS patients and the extent of tissue damage in the CC. Brain conventional and DTMRI scans were acquired from 54BMS patients and 21 healthy controls. Neuropsychological tests (NPT) exploring memory, attention, and frontal lobe cognitive domains were administered to the patients. DT tractography was used to calculate themean diffusivity (MD) and fractional anisotropy (FA) of the CC normal appearing white matter (NAWM). An index of CC atrophy was also estimated. Nine (17%) BMS patients fulfilled criteria for cognitive impairment. Compared with controls, BMS had significantly different CC diffusivity and volumetry (P <0.001). Compared with cognitively preserved patients, those with CI had significantly higher CC lesion volume (LV) (P = 0.02) andNAWMMD(P = 0.02). The scores obtained at PASAT were significantly correlated withCCT2 LV, andNAWMFA andMD(r values ranging from20.31 to 0.66, P values ranging from0.04 to

Original languageEnglish
Pages (from-to)2656-2666
Number of pages11
JournalHuman Brain Mapping
Volume30
Issue number8
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Corpus Callosum
Neuropsychological Tests
Anisotropy
Brain
Frontal Lobe
Sclerosis
Atrophy
Cognitive Dysfunction
Quality of Life

Keywords

  • Benign multiple sclerosis
  • Cognitive impairment
  • Corpus callosum
  • Diffusion tensor magnetic resonance imaging
  • Tractography
  • Voxel-based analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Corpus callosum damage and cognitive dysfunction in benign MS. / Mesaros, Sarlota; Rocca, Maria A.; Riccitelli, Gianna; Pagani, Elisabetta; Rovaris, Marco; Caputo, Domenico; Ghezzi, Angelo; Capra, Ruggero; Bertolotto, Antonio; Comi, Giancarlo; Filippi, Massimo.

In: Human Brain Mapping, Vol. 30, No. 8, 08.2009, p. 2656-2666.

Research output: Contribution to journalArticle

Mesaros, S, Rocca, MA, Riccitelli, G, Pagani, E, Rovaris, M, Caputo, D, Ghezzi, A, Capra, R, Bertolotto, A, Comi, G & Filippi, M 2009, 'Corpus callosum damage and cognitive dysfunction in benign MS', Human Brain Mapping, vol. 30, no. 8, pp. 2656-2666. https://doi.org/10.1002/hbm.20692
Mesaros, Sarlota ; Rocca, Maria A. ; Riccitelli, Gianna ; Pagani, Elisabetta ; Rovaris, Marco ; Caputo, Domenico ; Ghezzi, Angelo ; Capra, Ruggero ; Bertolotto, Antonio ; Comi, Giancarlo ; Filippi, Massimo. / Corpus callosum damage and cognitive dysfunction in benign MS. In: Human Brain Mapping. 2009 ; Vol. 30, No. 8. pp. 2656-2666.
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