Correction of increased prostacyclin synthesis in Bartter's syndrome by indometracin treatment

H. G. Gullner, J. B. Smith, C. Cerletti, J. R. Gill, F. C. Bartter

Research output: Contribution to journalArticle

Abstract

The role of prostacyclin and thromboxane A2 in the pathogenesis of Bartter's syndrome was investigated by measurement of the urinary excretion of 6-keto-PGF and thromboxane B2, respectively, in five patients. The prostaglandin metaeolites were extracted from urine by a reproducible method and measured by specific radioimmunoassays. The patients with Bartter's syndrome excreted about four-times as much 6-keto-PGF as the normal controls.In contrast, there was no significant difference in the urinary excretion of thromboxane B2 between the patients and the controls. In a second part of the study, three patients were treated with indomethacin (150 mg/day for four days), an inhibitor of prostaglandin synthesis. This regimen suppressed urinary excretion of 6-keto-PGF by 437 and that of thromboxane B2 by 467. It is suggested that the increase in prostacyclin production is responsible for both the hyperreninemia and the other endocrine derangements as well as the hyporesponsiveness of blood pressure to intravenous infusion of vasopressors in patients with Bartter's syndrome.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalProstaglandines and Medicine
Volume4
Issue number2
DOIs
Publication statusPublished - 1980

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Bartter Syndrome
Epoprostenol
Thromboxane B2
Therapeutics
Prostaglandin Antagonists
Thromboxane A2
Prostaglandins F
Intravenous Infusions
Indomethacin
Prostaglandins
Radioimmunoassay
Urine
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

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Correction of increased prostacyclin synthesis in Bartter's syndrome by indometracin treatment. / Gullner, H. G.; Smith, J. B.; Cerletti, C.; Gill, J. R.; Bartter, F. C.

In: Prostaglandines and Medicine, Vol. 4, No. 2, 1980, p. 65-72.

Research output: Contribution to journalArticle

Gullner, H. G. ; Smith, J. B. ; Cerletti, C. ; Gill, J. R. ; Bartter, F. C. / Correction of increased prostacyclin synthesis in Bartter's syndrome by indometracin treatment. In: Prostaglandines and Medicine. 1980 ; Vol. 4, No. 2. pp. 65-72.
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