Correction of mitral regurgitation in nonresponders to cardiac resynchronization therapy by MitraClip improves symptoms and promotes reverse remodeling

Angelo Auricchio, Wolfgang Schillinger, Sven Meyer, Francesco Maisano, Rainer Hoffmann, Gian Paolo Ussia, Giovanni B. Pedrazzini, Jan Van Der Heyden, Simona Fratini, Catherine Klersy, Jan Komtebedde, Olaf Franzen

Research output: Contribution to journalArticle

Abstract

Objectives: This study evaluated the safety, efficacy, and effect of MitraClip treatment on symptoms and left ventricular (LV) remodeling in nonresponders to cardiac resynchronization therapy (CRT). Background: Moderate to severe functional mitral regurgitation (FMR) frequently persists after CRT, contributing to reduced or no response to CRT. Percutaneous repair with the MitraClip has been proposed as an additional therapeutic option in select patients with significant FMR. Methods: Fifty-one severely symptomatic CRT nonresponders with significant FMR (grade

Original languageEnglish
Pages (from-to)2283-2289
Number of pages7
JournalJournal of the American College of Cardiology
Volume58
Issue number21
DOIs
Publication statusPublished - Nov 15 2011

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Keywords

  • cardiac resynchronization therapy
  • heart failure
  • mitral regurgitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Auricchio, A., Schillinger, W., Meyer, S., Maisano, F., Hoffmann, R., Ussia, G. P., Pedrazzini, G. B., Van Der Heyden, J., Fratini, S., Klersy, C., Komtebedde, J., & Franzen, O. (2011). Correction of mitral regurgitation in nonresponders to cardiac resynchronization therapy by MitraClip improves symptoms and promotes reverse remodeling. Journal of the American College of Cardiology, 58(21), 2283-2289. https://doi.org/10.1016/j.jacc.2011.06.061