TY - JOUR
T1 - Correlates and predictors of adherence to highly active antiretroviral therapy
T2 - Overview of published literature
AU - Ammassari, Adriana
AU - Trotta, Maria Paola
AU - Murri, Rita
AU - Castelli, Francesco
AU - Narciso, Pasquale
AU - Noto, Pasquale
AU - Vecchiet, Jacopo
AU - D'Arminio Monforte, Antonella
AU - Wu, Albert W.
AU - Antinori, Andrea
PY - 2002/12/15
Y1 - 2002/12/15
N2 - Knowledge of factors associated with medication adherence could help HIV clinicians to target persons in need of intervention, design these interventions, and help researchers to plan studies of adherence. This review summarizes the results of 20 studies investigating the issue of barriers to optimal highly active antiretroviral therapy (HAART) adherence. Only a few determinants were consistently associated with nonadherence. Symptoms and adverse drug effects, psychologic distress, lack of social or family support, complexity of the HAART regimen, low patient self-efficacy, and inconvenience of treatment were the factors most consistently associated with nonadherence. There were inconsistent findings regarding the relationship of adherence and the following variables: sociodemographic characteristics, substance abuse, depressive symptoms, quality of life, CD4+ cell count, knowledge and beliefs about treatment, patients' satisfaction with health care, and patient-provider relationship. A synthesis of findings relating various factors to adherence to HAART is difficult to reach because of several limitations of the existing body of research. These limitations concern the measurement of adherence, the assessment of correlates and predictors of adherence, the study population, and the study design.
AB - Knowledge of factors associated with medication adherence could help HIV clinicians to target persons in need of intervention, design these interventions, and help researchers to plan studies of adherence. This review summarizes the results of 20 studies investigating the issue of barriers to optimal highly active antiretroviral therapy (HAART) adherence. Only a few determinants were consistently associated with nonadherence. Symptoms and adverse drug effects, psychologic distress, lack of social or family support, complexity of the HAART regimen, low patient self-efficacy, and inconvenience of treatment were the factors most consistently associated with nonadherence. There were inconsistent findings regarding the relationship of adherence and the following variables: sociodemographic characteristics, substance abuse, depressive symptoms, quality of life, CD4+ cell count, knowledge and beliefs about treatment, patients' satisfaction with health care, and patient-provider relationship. A synthesis of findings relating various factors to adherence to HAART is difficult to reach because of several limitations of the existing body of research. These limitations concern the measurement of adherence, the assessment of correlates and predictors of adherence, the study population, and the study design.
KW - Adherence
KW - Antiretroviral therapy
KW - Compliance
KW - HAART
KW - HIV/AIDS
UR - http://www.scopus.com/inward/record.url?scp=0037114856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037114856&partnerID=8YFLogxK
M3 - Article
C2 - 12562034
AN - SCOPUS:0037114856
VL - 31
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - SUPPL. 3
ER -