Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort.

Renee Turzanski-Fortner, Allison F. Vitonis, Helena Schock, Anika Husing, Theron Johnson, Raina N. Fichorova, Titilayo Fashemi, Hidemi S. Yamamoto, Anne Tjonneland, Louise Hansen, Kim Overvad, Marie Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Carlo La Vecchia, Domenico Palli, Sabina SieriRosario Tumino, Giuseppe Matullo, Amalia Mattiello, N. Charlotte Onland-Moret, Petra P H Peeters, Elisabete Weiderpass, Inger Torhild Gram, Mie Jareid, J. Ramon Quiros, Eric J. Duell, Maria-Jose Sanchez, Maria Dolores Chirlaque Lopez, Eva Ardanaz, Nerea Larranaga, Bjorn Nodin, Jenny Brandstedt, Annika Idahl, Kay Tee Khaw, Naomi E. Allen, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A. Merritt, Elio Riboli, Daniel W. Cramer, Rudolf Kaaks, Kathryn L. Terry

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. RESULTS: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p textless/= 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend textless/= 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p textless 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p textless/= 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (textless/= 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. CONCLUSIONS: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.
Original languageUndefined/Unknown
Pages (from-to)20
Number of pages1
JournalJournal of Ovarian Research
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • CA15.3, CA125, Early detection markers, HE4, Ovarian cancer

Cite this

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort. / Turzanski-Fortner, Renee; Vitonis, Allison F.; Schock, Helena; Husing, Anika; Johnson, Theron; Fichorova, Raina N.; Fashemi, Titilayo; Yamamoto, Hidemi S.; Tjonneland, Anne; Hansen, Louise; Overvad, Kim; Boutron-Ruault, Marie Christine; Kvaskoff, Marina; Severi, Gianluca; Boeing, Heiner; Trichopoulou, Antonia; Benetou, Vassiliki; La Vecchia, Carlo; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Matullo, Giuseppe; Mattiello, Amalia; Onland-Moret, N. Charlotte; Peeters, Petra P H; Weiderpass, Elisabete; Gram, Inger Torhild; Jareid, Mie; Quiros, J. Ramon; Duell, Eric J.; Sanchez, Maria-Jose; Chirlaque Lopez, Maria Dolores; Ardanaz, Eva; Larranaga, Nerea; Nodin, Bjorn; Brandstedt, Jenny; Idahl, Annika; Khaw, Kay Tee; Allen, Naomi E.; Gunter, Marc; Johansson, Mattias; Dossus, Laure; Merritt, Melissa A.; Riboli, Elio; Cramer, Daniel W.; Kaaks, Rudolf; Terry, Kathryn L.

In: Journal of Ovarian Research, Vol. 10, No. 1, 01.03.2017, p. 20.

Research output: Contribution to journalArticle

Turzanski-Fortner, R, Vitonis, AF, Schock, H, Husing, A, Johnson, T, Fichorova, RN, Fashemi, T, Yamamoto, HS, Tjonneland, A, Hansen, L, Overvad, K, Boutron-Ruault, MC, Kvaskoff, M, Severi, G, Boeing, H, Trichopoulou, A, Benetou, V, La Vecchia, C, Palli, D, Sieri, S, Tumino, R, Matullo, G, Mattiello, A, Onland-Moret, NC, Peeters, PPH, Weiderpass, E, Gram, IT, Jareid, M, Quiros, JR, Duell, EJ, Sanchez, M-J, Chirlaque Lopez, MD, Ardanaz, E, Larranaga, N, Nodin, B, Brandstedt, J, Idahl, A, Khaw, KT, Allen, NE, Gunter, M, Johansson, M, Dossus, L, Merritt, MA, Riboli, E, Cramer, DW, Kaaks, R & Terry, KL 2017, 'Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort.', Journal of Ovarian Research, vol. 10, no. 1, pp. 20. https://doi.org/10.1186/s13048-017-0315-6
Turzanski-Fortner, Renee ; Vitonis, Allison F. ; Schock, Helena ; Husing, Anika ; Johnson, Theron ; Fichorova, Raina N. ; Fashemi, Titilayo ; Yamamoto, Hidemi S. ; Tjonneland, Anne ; Hansen, Louise ; Overvad, Kim ; Boutron-Ruault, Marie Christine ; Kvaskoff, Marina ; Severi, Gianluca ; Boeing, Heiner ; Trichopoulou, Antonia ; Benetou, Vassiliki ; La Vecchia, Carlo ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Matullo, Giuseppe ; Mattiello, Amalia ; Onland-Moret, N. Charlotte ; Peeters, Petra P H ; Weiderpass, Elisabete ; Gram, Inger Torhild ; Jareid, Mie ; Quiros, J. Ramon ; Duell, Eric J. ; Sanchez, Maria-Jose ; Chirlaque Lopez, Maria Dolores ; Ardanaz, Eva ; Larranaga, Nerea ; Nodin, Bjorn ; Brandstedt, Jenny ; Idahl, Annika ; Khaw, Kay Tee ; Allen, Naomi E. ; Gunter, Marc ; Johansson, Mattias ; Dossus, Laure ; Merritt, Melissa A. ; Riboli, Elio ; Cramer, Daniel W. ; Kaaks, Rudolf ; Terry, Kathryn L. / Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort. In: Journal of Ovarian Research. 2017 ; Vol. 10, No. 1. pp. 20.
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title = "Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort.",
abstract = "BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. RESULTS: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p textless/= 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend textless/= 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p textless 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p textless/= 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (textless/= 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. CONCLUSIONS: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.",
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author = "Renee Turzanski-Fortner and Vitonis, {Allison F.} and Helena Schock and Anika Husing and Theron Johnson and Fichorova, {Raina N.} and Titilayo Fashemi and Yamamoto, {Hidemi S.} and Anne Tjonneland and Louise Hansen and Kim Overvad and Boutron-Ruault, {Marie Christine} and Marina Kvaskoff and Gianluca Severi and Heiner Boeing and Antonia Trichopoulou and Vassiliki Benetou and {La Vecchia}, Carlo and Domenico Palli and Sabina Sieri and Rosario Tumino and Giuseppe Matullo and Amalia Mattiello and Onland-Moret, {N. Charlotte} and Peeters, {Petra P H} and Elisabete Weiderpass and Gram, {Inger Torhild} and Mie Jareid and Quiros, {J. Ramon} and Duell, {Eric J.} and Maria-Jose Sanchez and {Chirlaque Lopez}, {Maria Dolores} and Eva Ardanaz and Nerea Larranaga and Bjorn Nodin and Jenny Brandstedt and Annika Idahl and Khaw, {Kay Tee} and Allen, {Naomi E.} and Marc Gunter and Mattias Johansson and Laure Dossus and Merritt, {Melissa A.} and Elio Riboli and Cramer, {Daniel W.} and Rudolf Kaaks and Terry, {Kathryn L.}",
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TY - JOUR

T1 - Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort.

AU - Turzanski-Fortner, Renee

AU - Vitonis, Allison F.

AU - Schock, Helena

AU - Husing, Anika

AU - Johnson, Theron

AU - Fichorova, Raina N.

AU - Fashemi, Titilayo

AU - Yamamoto, Hidemi S.

AU - Tjonneland, Anne

AU - Hansen, Louise

AU - Overvad, Kim

AU - Boutron-Ruault, Marie Christine

AU - Kvaskoff, Marina

AU - Severi, Gianluca

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Benetou, Vassiliki

AU - La Vecchia, Carlo

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Matullo, Giuseppe

AU - Mattiello, Amalia

AU - Onland-Moret, N. Charlotte

AU - Peeters, Petra P H

AU - Weiderpass, Elisabete

AU - Gram, Inger Torhild

AU - Jareid, Mie

AU - Quiros, J. Ramon

AU - Duell, Eric J.

AU - Sanchez, Maria-Jose

AU - Chirlaque Lopez, Maria Dolores

AU - Ardanaz, Eva

AU - Larranaga, Nerea

AU - Nodin, Bjorn

AU - Brandstedt, Jenny

AU - Idahl, Annika

AU - Khaw, Kay Tee

AU - Allen, Naomi E.

AU - Gunter, Marc

AU - Johansson, Mattias

AU - Dossus, Laure

AU - Merritt, Melissa A.

AU - Riboli, Elio

AU - Cramer, Daniel W.

AU - Kaaks, Rudolf

AU - Terry, Kathryn L.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. RESULTS: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p textless/= 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend textless/= 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p textless 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p textless/= 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (textless/= 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. CONCLUSIONS: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.

AB - BACKGROUND: Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. METHODS: We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of prediction models adjusting for correlates of the markers were evaluated among postmenopausal women in the nested case-control study (n = 590 cases). Generalized linear models were used to calculate geometric means of CA125, CA15.3, and HE4. CA72.4 above vs. below limit of detection was evaluated using logistic regression. Early detection prediction was modeled using conditional logistic regression. RESULTS: CA125 concentrations were lower, and CA15.3 higher, in post- vs. premenopausal women (p textless/= 0.02). Among postmenopausal women, CA125 was higher among women with higher parity and older age at menopause (ptrend textless/= 0.02), but lower among women reporting oophorectomy, hysterectomy, ever use of estrogen-only hormone therapy, or current smoking (p textless 0.01). CA15.3 concentrations were higher among heavier women and in former smokers (p textless/= 0.03). HE4 was higher with older age at blood collection and in current smokers, and inversely associated with OC use duration, parity, and older age at menopause (textless/= 0.02). No associations were observed with CA72.4. Adjusting for correlates of the markers in prediction models did not improve the discrimination. CONCLUSIONS: This study provides insights into sources of variation in ovarian cancer early detection markers in healthy women and informs about the utility of individualizing marker cutpoints based on epidemiologic factors.

KW - CA15.3, CA125, Early detection markers, HE4, Ovarian cancer

U2 - 10.1186/s13048-017-0315-6

DO - 10.1186/s13048-017-0315-6

M3 - Articolo

VL - 10

SP - 20

JO - Journal of Ovarian Research

JF - Journal of Ovarian Research

SN - 1757-2215

IS - 1

ER -