Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma

Elizabeth E. Brown, Denise Whitby, Francesco Vitale, Paola Cordiali Fei, Carla Del Carpio, Vickie Marshall, Anthony J. Alberg, Diego Serraino, Angelo Messina, Lorenzo Gafa, James J. Goedert, Nino Romano, Francesca Ajello, Filippa Bonura, Anna Maria Perna, Enza Viviano, Fabio Tramuto, Maria Rosaria Villafrate, Maria Antonella Di Benedetto, Mario TamburiniMauizio Montella, Anna Crispo, Sonia De Sicato, Maria Rosaria De Marco, Paolo Ascierto, Pierluca Piselli, Giovanni Rezza, Catia Valdarchi, Rosa Maria Corona, Massimo Giuliani, Concetta Castilletti, Carmela Lauria, Caruso Laura, Stefania Stella, Michele Massimino, Barbara Kroner, Robert J. Biggar, Charles S. Rabkin

Research output: Contribution to journalArticle

Abstract

Background: The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined. Methods: We assessed correlates of HHV8-DNA detection among Italian adults without KS who had antibodies against HHV8-latent nuclear antigen by immunofluorescence assay. HHV8-K6 DNA sequences were detected in peripheral blood mononuclear cells using TaqMan CR. Results: Of the 158 subjects 26 (16.5%) had detectable HHV8-DNA [median copies/million cells, 53; (13-2128)]. Adjusted for age, sex, and laboratory, HHV8-DNA was detected more frequently in participants with >7 total residents in the childhood home [OR = 3.7 (1.5-9.1)], >2 younger siblings [OR = 2.6 (1.1-6.5)], and current cardiovascular [OR = 3.6 (1.3-9.7)] or renal [OR = 3.1 (1.2-8.0)] disease. Excluding the participants using immune modulating drugs, HHV8-DNA was more frequent among those with low red blood cells (RBC) [6/ μl; OR = 5.3 (1.7-16.2)], slightly elevated mean corpuscular volume [>92 μm3/red cell; OR = 2.8 (1.0-7.8)], and mild thrombocytopenia [

Original languageEnglish
Pages (from-to)1110-1117
Number of pages8
JournalInternational Journal of Epidemiology
Volume34
Issue number5
DOIs
Publication statusPublished - Oct 2005

Keywords

  • HHV8
  • Kaposi sarcoma herpesvirus
  • KSHV
  • Viral DNA
  • Viral load

ASJC Scopus subject areas

  • Epidemiology

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    Brown, E. E., Whitby, D., Vitale, F., Fei, P. C., Del Carpio, C., Marshall, V., Alberg, A. J., Serraino, D., Messina, A., Gafa, L., Goedert, J. J., Romano, N., Ajello, F., Bonura, F., Perna, A. M., Viviano, E., Tramuto, F., Villafrate, M. R., Di Benedetto, M. A., ... Rabkin, C. S. (2005). Correlates of Human Herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma. International Journal of Epidemiology, 34(5), 1110-1117. https://doi.org/10.1093/ije/dyi131