Correlation analysis between different parameters of conduit artery and microvascular vasodilation

Tommaso Gori, Giuseppe Di Stolfo, Silvia Sicuro, Saverio Dragoni, Monica Lisi, John D. Parker, Sandro Forconi

Research output: Contribution to journalArticlepeer-review

Abstract

Impaired endothelial responsiveness to specific vasodilator stimuli has been used as a surrogate marker of cardiovascular risk. Multiple methods allow testing endothelial responses in both microvessels and conduit arteries, but it is still unclear whether there is a relationship in endothelial function between these two different vascular beds. Twenty-five healthy young non smoking male volunteers (age range 24-45) were enrolled. Radial (conduit) artery (endothelium-dependent) flow-mediated dilation (FMD), microvascular cutaneous reactive hyperemia (using laser Doppler) and acetylcholine-induced microvascular vasodilation (laser Doppler iontophoresis) were measured. Data were analyzed in a randomized fashion in order to test the existence of a correlation among these measures of endothelium (in)dependent vasodilation. Conduit artery FMD showed a negative correlation with resting radial artery diameter (R=0.44, P

Original languageEnglish
Pages (from-to)509-515
Number of pages7
JournalClinical Hemorheology and Microcirculation
Volume35
Issue number4
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Hematology
  • Physiology

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