Correlation between a patient-derived functional questionnaire and abnormal neuromuscular transmission in Myasthenia Gravis patients

Anna Rostedt, Luca Padua, Erik V. Stålberg

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To correlate the patient-derived physical function score, as measured by the disease specific Myasthenia Gravis Questionnaire (MGQ), and the score obtained with commonly used generic 36-item questionnaire, the Short-Form health survey (SF-36), with the degree of abnormal neuromuscular transmission measured by Single-Fibre EMG (SFEMG) and repetitive nerve stimulation (RNS) in Myasthenia Gravis (MG) patients. Methods: SFEMG and RNS were performed in the deltoid muscle and SFEMG was also performed in the orbicularis oculi muscle in 45 MG patients. The patients were asked to fill out the MGQ, which has been translated and validated into Swedish, and the SF-36. The sum of MGQ items generates a global MGQ score. Items are also divided into 3 muscle specific domains: generalized, bulbar and ocular. Results: The global MGQ score and generalized domain score of MGQ were strongly correlated with the degree of abnormal neuromuscular transmission, as measured by SFEMG in the deltoid muscle. Scores from ocular and bulbar domains of MGQ were not related to neurophysiological findings. Physical composite scores of SF-36 correlated significantly with the abnormal SFEMG findings in the deltoid. Conclusions: The degree of disturbed neuromuscular transmission in a proximal limb muscle correlates with a patient's subjective experience of generalized myasthenic dysfunction. Significance: The observed correlation adds a new dimension to neurophysiological examinations in patients with MG.

Original languageEnglish
Pages (from-to)2058-2064
Number of pages7
JournalClinical Neurophysiology
Volume116
Issue number9
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Myasthenia Gravis
Deltoid Muscle
Muscles
Surveys and Questionnaires
Muscle Weakness
Health Surveys
Extremities

Keywords

  • MG questionnaire
  • Myasthenia gravis
  • Neuromuscular
  • Patient-derived
  • Quality of life
  • Single-fibre EMG

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Correlation between a patient-derived functional questionnaire and abnormal neuromuscular transmission in Myasthenia Gravis patients. / Rostedt, Anna; Padua, Luca; Stålberg, Erik V.

In: Clinical Neurophysiology, Vol. 116, No. 9, 09.2005, p. 2058-2064.

Research output: Contribution to journalArticle

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