Abstract
Samples of 18 osteosarcomas were examined for the occurrence of apoptosis and TP53 status. Apoptosis was investigated by an in situ nick translation technique on paraffin-embedded samples. It was found that apoptosis rarely occurs in osteosarcoma at the early stage of disease, whereas it is frequently activated when tumors are treated with antiblastic drugs. The analysis of the TP53 gene showed no mutation at diagnosis; whereas, during disease progression, four cases showed TP53 mutations. The authors discuss the relation between apoptosis, TP53 status, and therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 177-181 |
| Number of pages | 5 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 105 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Sep 1998 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
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Correlation between apoptosis and TP53 status in osteosarcoma. / Pompetti, Franca; Stuppia, Liborio; Gatta, Valentina; Calabrese, Giuseppe; Gamberi, Gabriella; Benassi, Maria Serena; Picci, Piero; Palka, Giandomenico.
In: Cancer Genetics and Cytogenetics, Vol. 105, No. 2, 09.1998, p. 177-181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation between apoptosis and TP53 status in osteosarcoma
AU - Pompetti, Franca
AU - Stuppia, Liborio
AU - Gatta, Valentina
AU - Calabrese, Giuseppe
AU - Gamberi, Gabriella
AU - Benassi, Maria Serena
AU - Picci, Piero
AU - Palka, Giandomenico
PY - 1998/9
Y1 - 1998/9
N2 - Samples of 18 osteosarcomas were examined for the occurrence of apoptosis and TP53 status. Apoptosis was investigated by an in situ nick translation technique on paraffin-embedded samples. It was found that apoptosis rarely occurs in osteosarcoma at the early stage of disease, whereas it is frequently activated when tumors are treated with antiblastic drugs. The analysis of the TP53 gene showed no mutation at diagnosis; whereas, during disease progression, four cases showed TP53 mutations. The authors discuss the relation between apoptosis, TP53 status, and therapy.
AB - Samples of 18 osteosarcomas were examined for the occurrence of apoptosis and TP53 status. Apoptosis was investigated by an in situ nick translation technique on paraffin-embedded samples. It was found that apoptosis rarely occurs in osteosarcoma at the early stage of disease, whereas it is frequently activated when tumors are treated with antiblastic drugs. The analysis of the TP53 gene showed no mutation at diagnosis; whereas, during disease progression, four cases showed TP53 mutations. The authors discuss the relation between apoptosis, TP53 status, and therapy.
UR - http://www.scopus.com/inward/record.url?scp=0032171324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032171324&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(98)00026-0
DO - 10.1016/S0165-4608(98)00026-0
M3 - Article
C2 - 9723038
AN - SCOPUS:0032171324
VL - 105
SP - 177
EP - 181
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -