Correlation between apoptosis and TP53 status in osteosarcoma

Franca Pompetti, Liborio Stuppia, Valentina Gatta, Giuseppe Calabrese, Gabriella Gamberi, Maria Serena Benassi, Piero Picci, Giandomenico Palka

Research output: Contribution to journalArticlepeer-review

Abstract

Samples of 18 osteosarcomas were examined for the occurrence of apoptosis and TP53 status. Apoptosis was investigated by an in situ nick translation technique on paraffin-embedded samples. It was found that apoptosis rarely occurs in osteosarcoma at the early stage of disease, whereas it is frequently activated when tumors are treated with antiblastic drugs. The analysis of the TP53 gene showed no mutation at diagnosis; whereas, during disease progression, four cases showed TP53 mutations. The authors discuss the relation between apoptosis, TP53 status, and therapy.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume105
Issue number2
DOIs
Publication statusPublished - Sep 1998

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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