TY - JOUR
T1 - Correlation between beta-endorphin plasma levels and anginal symptoms in patients with coronary artery disease
AU - Falcone, Colomba
AU - Specchia, Giuseppe
AU - Rondanelli, Renato
AU - Guasti, Luigina
AU - Corsico, Giovanna
AU - Codega, Silvia
AU - Montemartini, Carlo
PY - 1988
Y1 - 1988
N2 - To verify whether beta-endorphin plasma levels influence the presence of anginal symptoms. 74 consecutive male patients were studied. All patients had previously documented coronary artery disease and reproducible exerciseinduced myocardial ischemia. Thirty-five patients (Group I) had a history of angina and reported anginal symptoms during exercise stress testing; 39 patients (Group II) were asymptomatic and had documented silent myocardial ischemia during exercise. Baseline beta-endorphin plasma levels were measured in blood ramples taken before exercise stress testing and analyzed by beta-endorphin-I125-RIA Kit-NEN (a radioimmunoassay method). The mean baseline beta-eadorphin plasma level was 22.5 ± 19 pg/ml in patients with anginal symptoms compared with 43.7 ± 28 pg/ml in asymptomatic patients (p <0.001). Baseline blood pressure and heart rate-systolic pressure (rate-pressure) product at baseline and at ischemia threshold (1 mm ST segment depression) were similar in the two groups, Group II patients had a longer exercise duration p <0.01), more pronounced ST segment depression (p <0.001) and a higher peak rate-pressure product (p <0.01). The extent of coronary artery disease, ejection fraction and left ventricular end-diastolic pressure were similar in the two groups. These data suggest that higher baseline bata-endorphin plasma levels may play a role in the decreased sensitevity to pain in patients with slient myocardial ischemia. In addition, different beta-endorphin levels can be associated with a different sensitivity to pain.
AB - To verify whether beta-endorphin plasma levels influence the presence of anginal symptoms. 74 consecutive male patients were studied. All patients had previously documented coronary artery disease and reproducible exerciseinduced myocardial ischemia. Thirty-five patients (Group I) had a history of angina and reported anginal symptoms during exercise stress testing; 39 patients (Group II) were asymptomatic and had documented silent myocardial ischemia during exercise. Baseline beta-endorphin plasma levels were measured in blood ramples taken before exercise stress testing and analyzed by beta-endorphin-I125-RIA Kit-NEN (a radioimmunoassay method). The mean baseline beta-eadorphin plasma level was 22.5 ± 19 pg/ml in patients with anginal symptoms compared with 43.7 ± 28 pg/ml in asymptomatic patients (p <0.001). Baseline blood pressure and heart rate-systolic pressure (rate-pressure) product at baseline and at ischemia threshold (1 mm ST segment depression) were similar in the two groups, Group II patients had a longer exercise duration p <0.01), more pronounced ST segment depression (p <0.001) and a higher peak rate-pressure product (p <0.01). The extent of coronary artery disease, ejection fraction and left ventricular end-diastolic pressure were similar in the two groups. These data suggest that higher baseline bata-endorphin plasma levels may play a role in the decreased sensitevity to pain in patients with slient myocardial ischemia. In addition, different beta-endorphin levels can be associated with a different sensitivity to pain.
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U2 - 10.1016/0735-1097(88)90202-1
DO - 10.1016/0735-1097(88)90202-1
M3 - Article
C2 - 2965173
AN - SCOPUS:0023874669
VL - 11
SP - 719
EP - 723
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 4
ER -