Correlation between brain MRI lesion volume and disability in patients with multiple sclerosis

S. Mammi, M. Filippi, V. Martinelli, A. Campi, B. Colombo, G. Scotti, N. Canal, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we evaluated the relationships between clinical variables and lesion volumes measured from magnetic resonance imaging (MRI) scans in a large cohort of multiple sclerosis (MS) patients. One hundred and thirty patients with MS entered the study: 36 patients had relapsing-remitting (RR), 39 benign (B), 42 secondary progressive (SP) and 13 primary progressive (PP) courses. There was a significant correlation (r=0.3; p=0.0006) between the total lesion load and the EDSS score when the whole cohort of patients was considered. This correlation increased (r=0.5) when only patients with RRMS and SPMS were considered. Our data indicate that a correlation between disability and MRI lesion volume in MS exists, but its strength is moderate.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalActa Neurologica Scandinavica
Volume94
Issue number2
Publication statusPublished - 1996

Keywords

  • Brain magnetic resonance imaging
  • Disability
  • Lesion volume
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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